Synthesis, spectral characterization and biological studies of quinoline based ligands and their transition metal complexes

被引：2
|
作者：
Narayanachar [1 ,2 ]
Dhumwad, Shreedhar D. [1 ]
Suresh, D. K. [3 ]
机构：
[1] Karnatak Univ, Dept Chem, Karnatak Sci Coll, Dharwad 580001, Karnataka, India
[2] Laxmi Venktesh Desai Coll, Dept Chem, Raichur, Karnataka, India
[3] Luqman Coll Pharm, Dept Pharmacol, Gulbarga, Karnataka, India
来源：
MAIN GROUP CHEMISTRY | 2012年 / 11卷 / 02期
关键词：
Quinoline; diaminonaphthalene; coordination; antimicrobial; analgesic; anti-inflammatory; DNA-BINDING; SUBSTITUTED QUINOLINES; COPPER(II) COMPLEXES; CU(II) COMPLEXES; MACROCYCLIC COMPLEXES; CLEAVAGE; DERIVATIVES; KINETICS;
D O I：
10.3233/MGC-2012-0066
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
A series novel Schiff bases derived from 2-mercapto-3-formyl quinoline/2-hydroxy-3-formyl quinoline with 1,8-diaminonaphthalene (DAN) and its corresponding transition metal complexes of Co (II), Ni(II), Cu(II) and Zn (II) were synthesized, characterized by elemental analysis, spectral (IR, H-1-NMR, Mass, UV-Vis, Fluorescence, ESR, TGA) and magnetic studies. The results indicated that all the metal complexes possess octahedral geometry. The measured molar conductance in DMF indicates that the complexes are non-electrolytic in nature. These Schiff bases and metal complexes have been screened for antibacterial, antifungal activities by MIC method and further evaluated for anti-inflammatory and analgesic activity by carrageenan induced paw oedema and tail flick methods in rats.
引用
收藏
页码：135 / 149
页数：15
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