Efficacy of low and high fixed dose radioactive iodine therapy in patients with toxic nodular goiter

被引：0
|
作者：
Sonmez, B. [1 ]
Erem, C. [2 ]
Dogan, I. [1 ]
Ersoz, H. O. [2 ]
Sonmez, M. [3 ]
机构：
[1] Karadeniz Tech Univ, Sch Med, Dept Nucl Med, TR-61080 Trabzon, Turkey
[2] Karadeniz Tech Univ, Sch Med, Dept Endocrinol & Metab, TR-61080 Trabzon, Turkey
[3] Karadeniz Tech Univ, Sch Med, Dept Hematol, TR-61080 Trabzon, Turkey
来源：
MINERVA ENDOCRINOLOGICA | 2011年 / 36卷 / 02期
关键词：
Goiter; Therapeutics; Iodine Radioisotopes; TERM-FOLLOW-UP; RADIOIODINE TREATMENT; PROGNOSTIC-FACTORS; GRAVES-DISEASE; I-131; THERAPY; HYPERTHYROIDISM; THYROTOXICOSIS; PROPYLTHIOURACIL; PRETREATMENT; PROTOCOLS;
D O I：
暂无
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
Aim. The efficacy of low and high fixed dose radioactive iodine (RAI) therapy in patients with toxic nodular goiter was investigated. Methods. Ninety-three patients (25 males, 68 females) were included into the study (32 patients with toxic adenoma, 61 patients with toxic multinodular goiter). Patients were treated with a fixed dose of 370 MBq (10 mCi) or 740 MBq (20 mCi) RAI. The average follow-up period was 17 +/- 10 months. Results. The overall cure rate (eutyhroidism and hypothyroidism) was 81% in patients treated with 740 MBq RAI and 51% in patients treated with 370 MBq RAI (p<0.05). RAI therapy with a dose of 370 MBq and 740 MBq provided the cure in 73% and 91% of the patients with toxic adenoma and 42% and 76% of the patients with toxic multinodular goiter, respectively. No significant difference for gender was observed. Hypothyroidism developed in 4 and 15 patients with a dose of 370 MBq and 740 MBq RAI, respectively. Conclusion. A dose of 740 MBq RAI was found to be more effective for the treatment of toxic nodular goiter as compared to a dose of 370 MBq RAI.
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页码：117 / 121
页数：5
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