Recent advances in the development of immunotherapies for tauopathies

被引：12
|
作者：
Ubhi, Kiren [1 ]
Masliah, Eliezer [1 ,2 ]
机构：
[1] Univ Calif San Diego, Dept Neurosci, La Jolla, CA 92093 USA
[2] Univ Calif San Diego, Dept Pathol, La Jolla, CA 92093 USA
来源：
EXPERIMENTAL NEUROLOGY | 2011年 / 230卷 / 02期
关键词：
PAIRED HELICAL FILAMENTS; BETA-AMYLOID PROTEIN; ALZHEIMERS-DISEASE; MOUSE MODEL; NEUROFIBRILLARY TANGLES; TRANSGENIC MICE; TAU-PROTEIN; PHOSPHORYLATED-TAU; GAMMA-SECRETASE; SYNAPSE LOSS;
D O I：
10.1016/j.expneurol.2010.10.007
中图分类号：
Q189 [神经科学];
学科分类号：
071006 ;
摘要：
The use of immunotherapy for Alzheimer's disease (AD) has traditionally focused on the amyloid-beta (A beta) peptide and has shown great potential in both animal and human studies. However, an emerging body of work has begun to concentrate on tau and to develop immunization protocols designed to decrease tau pathology in AD and other tauopathies. This commentary will discuss the use of immunotherapy for AD, focusing on tau immunotherapy in the context of recent reports on the use of tau phospho-peptides in transgenic models of tau pathology. (C) 2010 Elsevier Inc. All rights reserved.
引用
收藏
页码：157 / 161
页数：5
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