Merkel cell polyomavirus (MCPyV) in chronic lymphocytic leukemia/small lymphocytic lymphoma

被引：42
|
作者：
Teman, Carolin J. [1 ]
Tripp, Sheryl R. [2 ]
Perkins, Sherrie L. [1 ,2 ]
Duncavage, Eric J. [1 ]
机构：
[1] Univ Utah, Dept Pathol, Salt Lake City, UT 84108 USA
[2] ARUP Inst Clin & Expt Pathol, Salt Lake City, UT USA
来源：
LEUKEMIA RESEARCH | 2011年 / 35卷 / 05期
关键词：
Chronic lymphocytic leukemia; Small lymphocytic lymphoma; MCPyV; CLL; SLL; Polyomavirus; CARCINOMA; EXPRESSION; MCV;
D O I：
10.1016/j.leukres.2011.01.032
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
Merkel cell polyomavirus (MCPyV) is a novel polyomavirus that shows a strong association with Merkel cell carcinoma (MCC). Recent studies have demonstrated MCPyV in some cases of chronic lymphocytic leukemia/small lymphocytic lymphoma (CLL/SLL), a malignancy with a similar demographic as MCC. We tested for the presence of MCPyV by PCR and immunohistochemistry in 18 cases of CLL/SLL. Very low-level MCPyV DNA was detected in 33% of CLL/SLL cases by real-time PCR, but only one case demonstrated immunohistochemical positivity for MCPyV. MCPyV was not identified in 17 cases of follicular lymphoma, suggesting either that MCPyV is involved in CLL/SLL pathogenesis or that the immunodeficiency state of CLL/SLL induces low-level MCPyV reactivation. (C) 2011 Elsevier Ltd. All rights reserved.
引用
收藏
页码：689 / 692
页数：4
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