Enforced IL-10 expression confers Tr1 cell phenotype and functions to human CD4+T cells

被引：0
|
作者：
Andolfi, G. [1 ]
Rossetti, M. [1 ]
Magnani, C. F. [1 ]
Fousteri, G. [1 ]
Jofra, T. [3 ]
Gregori, S. [2 ]
Roncarolo, M. G. [2 ]
机构：
[1] Ist Sci San Raffaele, Dept Regenerat Med Stem Cells & Gene Therapy, San Raffaele Telethon Inst Gene Therapy HSR TIGET, I-20132 Milan, Italy
[2] Ist Sci San Raffaele, Dept Regenerat Med Stem Cells & Gene Therapy, Raffaele Telethon Inst Gene Therapy HSR TIGET, I-20132 Milan, Italy
[3] San Raffaele Diabet Res Inst HSR DRI, Dept Immunol Transplantat & Infect Dis, I-20132 Milan, Italy
来源：
HUMAN GENE THERAPY | 2010年 / 21卷 / 10期
关键词：
D O I：
暂无
中图分类号：
Q81 [生物工程学（生物技术）]; Q93 [微生物学];
学科分类号：
071005 ; 0836 ; 090102 ; 100705 ;
摘要：
引用
收藏
页码：1447 / 1447
页数：1
相关论文
共 50 条
  • [1] Enforced IL-10 Expression Confers Type 1 Regulatory T Cell (Tr1) Phenotype and Function to Human CD4+ T Cells
    Andolfi, Grazia
    Fousteri, Georgia
    Rossetti, Maura
    Magnani, Chiara F.
    Jofra, Tatiana
    Locafaro, Grazia
    Bondanza, Attilio
    Gregori, Silvia
    Roncarolo, Maria-Grazia
    [J]. MOLECULAR THERAPY, 2012, 20 (09) : 1778 - 1790
  • [2] Ikaros regulates IL-10 expression in CD4+T cells
    Umetsu, Sarah E.
    Winandy, Susan
    [J]. JOURNAL OF IMMUNOLOGY, 2009, 182
  • [3] Differentiation of Tr1 cells by immature dendritic cells requires IL-10 but not CD25+CD4+ Tr cells
    Levings, MK
    Gregori, S
    Tresoldi, E
    Cazzaniga, S
    Bonini, C
    Roncarolo, MG
    [J]. BLOOD, 2005, 105 (03) : 1162 - 1169
  • [4] TNF-α blockade induces IL-10 expression in human CD4+T cells
    Evans, Hayley G.
    Roostalu, Urmas
    Walter, Gina J.
    Gullick, Nicola J.
    Frederiksen, Klaus S.
    Roberts, Ceri A.
    Sumner, Jonathan
    Baeten, Dominique L.
    Gerwien, Jens G.
    Cope, Andrew P.
    Geissmann, Frederic
    Kirkham, Bruce W.
    Taams, Leonie S.
    [J]. NATURE COMMUNICATIONS, 2014, 5
  • [5] Targeting of Myeloid Leukemia by IL-10-Engineered Human CD4+ Tr1 Cells
    Locafaro, Grazia
    Andolfi, Grazia
    Russo, Fabio
    Camisa, Barbara
    Ciceri, Fabio
    Lombardo, Angelo
    Bondanza, Attilio
    Roncarolo, Maria Grazia
    Gregori, Silvia
    [J]. MOLECULAR THERAPY, 2016, 24 : S252 - S252
  • [6] IL-10 Receptor Signaling Is Essential for TR1 Cell Function In Vivo
    Brockmann, Leonie
    Gagliani, Nicola
    Steglich, Babett
    Giannou, Anastasios D.
    Kempski, Jan
    Pelczar, Penelope
    Geffken, Maria
    Mfarrej, Bechara
    Huber, Francis
    Herkel, Johannes
    Wan, Yisong Y.
    Esplugues, Enric
    Battaglia, Manuela
    Krebs, Christian F.
    Flavell, Richard A.
    Huber, Samuel
    [J]. JOURNAL OF IMMUNOLOGY, 2017, 198 (03): : 1130 - 1141
  • [7] Transgenic human IL-10 expression by CD4+T cells is associated with resistance to colitis in I110-/- mice
    Bream, Jay
    Ramakrishnan, Amritha
    Wang, Fengying
    Brayton, Cory
    Ranatunga, Dilini
    [J]. JOURNAL OF IMMUNOLOGY, 2011, 186
  • [8] IL-10 suppressor activity and Tr1 cell function are impaired in multiple sclerosis
    Villoslada, Pablo
    Garcia-Munoz, Ricardo
    Inoges, Susana
    Lopez, Ascension
    Palacios, Ricardo
    Sepulcre, Jorge
    Melero, Ignacio
    Bendandi, Maurizio
    [J]. NEUROLOGY, 2007, 68 (12) : A396 - A396
  • [9] IL-10 regulates movement of intestinally derived CD4+T cells to the liver
    Bliss, Susan K.
    Bliss, Stuart P.
    Beiting, Daniel
    Alcaraz, Ana
    Appleton, Judith
    [J]. JOURNAL OF IMMUNOLOGY, 2007, 178
  • [10] CD4+T cell expression of the IL-10 receptor is necessary for facial motoneuron survival after axotomy
    Runge, Elizabeth M.
    Iyer, Abhirami K.
    Setter, Deborah O.
    Kennedy, Felicia M.
    Sanders, Virginia M.
    Jones, Kathryn J.
    [J]. JOURNAL OF NEUROINFLAMMATION, 2020, 17 (01)
12345