Application of CRISPR-Cas9 in eye disease

被引：8
|
作者：
Wu, Wenyi [1 ,2 ]
Tang, Luosheng [2 ]
D'Amore, Patricia A. [1 ,3 ]
Lei, Hetian [1 ]
机构：
[1] Harvard Med Sch, Schepens Eye Res Inst, Massachusetts Eye & Ear, Dept Ophthalmol, 20 Staniford St, Boston, MA 02114 USA
[2] Cent S Univ, Xiangya Hosp 2, Dept Ophthalmol, Changsha, Hunan, Peoples R China
[3] Harvard Med Sch, Dept Pathol, Boston, MA 02114 USA
来源：
EXPERIMENTAL EYE RESEARCH | 2017年 / 161卷
基金：
美国国家卫生研究院;
关键词：
STRAND BREAK REPAIR; COMPLETE GENOME SEQUENCE; PLURIPOTENT STEM-CELLS; GENE-THERAPY; HOMOLOGOUS RECOMBINATION; CONDITIONAL ALLELES; CAS SYSTEMS; RNA; CRISPR/CAS9; NUCLEASES;
D O I：
10.1016/j.exer.2017.06.007
中图分类号：
R77 [眼科学];
学科分类号：
100212 ;
摘要：
The system of clustered regularly interspaced short palindromic repeats (CRISPR) and CRISPR-associated nuclease (Cas)9 is an effective instrument for revising the genome with great accuracy. This system has been widely employed to generate mutants in genomes from plants to human cells. Rapid improvements in Cas9 specificity in eukaryotic cells have opened great potential for the use of this technology as a therapeutic. Herein, we summarize the recent advancements of CRISPR-Cas9 use in research on human cells and animal models, and outline a basic and clinical pipeline for CRISPR-Cas9-based treatments of genetic eye diseases. (C) 2017 Elsevier Ltd. All rights reserved.
引用
收藏
页码：116 / 123
页数：8
相关论文
共 50 条
  • [1] Advances in therapeutic application of CRISPR-Cas9
    Sun, Jinyu
    Wang, Jianchu
    Zheng, Donghui
    Hu, Xiaorong
    [J]. BRIEFINGS IN FUNCTIONAL GENOMICS, 2020, 19 (03) : 164 - 174
  • [2] CRISPR-Cas9 System and Its Application
    Benesova, Eva
    [J]. CHEMICKE LISTY, 2020, 114 (09): : 586 - 590
  • [3] Application of CRISPR-Cas9 gene editing for congenital heart disease
    Seok, Heeyoung
    Deng, Rui
    Cowan, Douglas B.
    Wang, Da-Zhi
    [J]. CLINICAL AND EXPERIMENTAL PEDIATRICS, 2021, 64 (06) : 269 - 279
  • [4] Role and application of CRISPR-Cas9 in the management of Alzheimer's disease
    Soni, Nilay
    Kar, Indrani
    Narendrasinh, Jadav Dhruvkumar
    Shah, Sanjay Kumar
    Konathala, Lohini
    Mohamed, Nadine
    Kachhadia, Meet Popatbhai
    Chaudhary, Mitul Hareshkumar
    Dave, Vyapti A.
    Kumar, Lakshya
    Ahmadi, Leeda
    Golla, Varshitha
    [J]. ANNALS OF MEDICINE AND SURGERY, 2024, 86 (03): : 1517 - 1521
  • [5] CRISPR-Cas9 Applications in Cardiovascular Disease
    Khouzam, John Paul S.
    Tivakaran, Vijai S.
    [J]. CURRENT PROBLEMS IN CARDIOLOGY, 2021, 46 (03)
  • [6] Advances and Perspectives in the Application of CRISPR-Cas9 in Livestock
    Abdul Jabbar
    Farheen Zulfiqar
    Mahnoor Mahnoor
    Nadia Mushtaq
    Muhammad Hamza Zaman
    Anum Salah Ud din
    Musarrat Abbas Khan
    Hafiz Ishfaq Ahmad
    [J]. Molecular Biotechnology, 2021, 63 : 757 - 767
  • [7] Application of CRISPR-Cas9 technology in diabetes research
    Lotfi, Malihe
    Butler, Alexandra E.
    Sukhorukov, Vasily N.
    Sahebkar, Amirhossein
    [J]. DIABETIC MEDICINE, 2024, 41 (01)
  • [8] Expanding application of CRISPR-Cas9 system in microorganisms
    Zhao, Jing
    Fang, Huan
    Zhang, Dawei
    [J]. SYNTHETIC AND SYSTEMS BIOTECHNOLOGY, 2020, 5 (04) : 269 - 276
  • [9] Advances and Perspectives in the Application of CRISPR-Cas9 in Livestock
    Jabbar, Abdul
    Zulfiqar, Farheen
    Mahnoor, Mahnoor
    Mushtaq, Nadia
    Zaman, Muhammad Hamza
    Din, Anum Salah Ud
    Khan, Musarrat Abbas
    Ahmad, Hafiz Ishfaq
    [J]. MOLECULAR BIOTECHNOLOGY, 2021, 63 (09) : 757 - 767
  • [10] Trends in CRISPR-Cas9 technology application in cancer
    Mukhopadhyay, Subhadip
    Bhutia, Sujit Kumar
    [J]. ADVANCES IN CRISPR/CAS AND RELATED TECHNOLOGIES, 2021, 178 : 175 - 192
12345