Ferroptosis execution: Is it all about ACSL4?

被引：12
|
作者：
Lee, Hyemin [1 ]
Gan, Boyi [1 ,2 ]
机构：
[1] Univ Texas MD Anderson Canc Ctr, Dept Expt Radiat Oncol, Houston, TX 77030 USA
[2] Univ Texas MD Anderson UTHlth, Grad Sch Biomed Sci, Houston, TX 77030 USA
来源：
CELL CHEMICAL BIOLOGY | 2022年 / 29卷 / 09期
基金：
美国国家卫生研究院;
关键词：
D O I：
10.1016/j.chembiol.2022.08.002
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
ACSL4 is generally considered to be universally required for ferroptosis, a form of cell death induced by phospholipid peroxidation. In this issue of Cell Chemical Biology, Magtanong et al. (2022) report the surprising finding that ACSL4 is only required for ferroptosis in certain circumstances, raising interesting questions about the regulation of this cell death pathway.
引用
收藏
页码：1363 / 1365
页数：3
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