Wychimicins, a new class of spirotetronate polyketides from Actinocrispum wychmicini MI503-A4

被引：3

作者：

Kimura, Tomoyuki ^{[1
]}

Umekita, Maya ^{[1
]}

Hatano, Masaki ^{[1
]}

Hayashi, Chigusa ^{[1
]}

Sawa, Ryuichi ^{[1
]}

Igarashi, Masayuki ^{[1
]}

机构：

[1] Inst Microbial Chem BIKAKEN, Shinagawa Ku, 3-14-23 Kamiosaki, Tokyo 1410021, Japan

来源：

JOURNAL OF ANTIBIOTICS | 2022年 / 75卷 / 10期

关键词：

STAPHYLOCOCCUS-AUREUS INFECTIONS; ANTI-TUMOR ANTIBIOTICS; METHICILLIN-RESISTANT; EPIDEMIOLOGY; FERMENTATION; KIJANIMICIN; INHIBITORS; BACTERIAL;

D O I：

10.1038/s41429-022-00560-4

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

In the course of our screening program for new anti-methicillin-resistant Staphylococcus aureus antibiotics, four novel antibiotics, termed wychimicins A-D, were isolated from the culture broth of the rare actinomycete Actinocrispum wychmicini strain MI503-AF4. Wychimicins are spirotetronates possessing a macrocyclic 13-membered ring containing trans-decalin and beta-d-xylo-hexopyranose moieties connected to C-17 by an O-glycosidic linkage according to MS, NMR and X-ray analyses. In X-ray crystal structure analysis, the Flack constant was 0.10 (11). The stereochemistry of the spirocarbon C-25 was R. Wychimicins had a minimum inhibitory concentration of 0.125-2 mu g ml(-1) against methicillin-resistant Staphylococcus aureus.

引用

页码：535 / 541

页数：7

共 50 条

[1] Wychimicins, a new class of spirotetronate polyketides from Actinocrispum wychmicini MI503-A4
Tomoyuki Kimura
Maya Umekita
Masaki Hatano
Chigusa Hayashi
Ryuichi Sawa
Masayuki Igarashi
[J]. The Journal of Antibiotics, 2022, 75 : 535 - 541
[2] Nomimicin, a new spirotetronate-class polyketide from an actinomycete of the genus Actinomadura
Yasuhiro Igarashi
Takako Iida
Naoya Oku
Hiroyuki Watanabe
Kazuo Furihata
Koji Miyanouchi
[J]. The Journal of Antibiotics, 2012, 65 : 355 - 359
[3] Nomimicin, a new spirotetronate-class polyketide from an actinomycete of the genus Actinomadura
Igarashi, Yasuhiro
Iida, Takako
Oku, Naoya
Watanabe, Hiroyuki
Furihata, Kazuo
Miyanouchi, Koji
[J]. JOURNAL OF ANTIBIOTICS, 2012, 65 (07): : 355 - 359
[4] Nomimicins B-D, new tetronate-class polyketides from a marine-derived actinomycete of the genus Actinomadura
Zhang, Zhiwei
Zhou, Tao
Yang, Taehui
Fukaya, Keisuke
Harunari, Enjuro
Saito, Shun
Yamada, Katsuhisa
Imada, Chiaki
Urabe, Daisuke
Igarashi, Yasuhiro
[J]. BEILSTEIN JOURNAL OF ORGANIC CHEMISTRY, 2021, 17 : 2194 - 2202
[5] New Polyketides from the Marine-Derived Fungus Letendraea Sp. 5XNZ4-2
Xu, Yan
Huang, Ruibao
Liu, Hongwei
Yan, Tingting
Ding, Wanjing
Jiang, Yongjun
Wang, Pinmei
Zheng, Daoqiong
Xu, Jinzhong
[J]. MARINE DRUGS, 2020, 18 (01)
[6] 4 NEW C-16 1,2-DIOXENE-POLYKETIDES FROM THE SPONGE PLAKORTIS-AFF-SIMPLEX
RUDI, A
TALPIR, R
KASHMAN, Y
BENAYAHU, Y
SCHLEYER, M
[J]. JOURNAL OF NATURAL PRODUCTS, 1993, 56 (12): : 2178 - 2182
[7] Three New Polyketides from the Insect-Associated Fungus Letendraea sp. 5XNZ4-2
Xu, Yan
Fu, Nanyan
Ding, Wanjing
Wang, Pinmei
Xu, Jinzhong
[J]. RECORDS OF NATURAL PRODUCTS, 2021, 15 (03) : 187 - 193
[8] A new class of differential 4-uniform permutations from exponential permutation
R. K. Sharma
P. R. Mishra
Yogesh Kumar
[J]. Applicable Algebra in Engineering, Communication and Computing, 2023, 34 : 897 - 912
[9] A new class of differential 4-uniform permutations from exponential permutation
Sharma, R. K.
Mishra, P. R.
Kumar, Yogesh
[J]. APPLICABLE ALGEBRA IN ENGINEERING COMMUNICATION AND COMPUTING, 2023, 34 (06) : 897 - 912
[10] Shikimerans B-D: New polyketides from the endophytic fungus Chaetomium sp. FZ-4 of Aconitum carmichaelii Debx
Chen, Xiaojing
Ruan, Qingfeng
Zheng, Xiaoyun
Xuan, Shenxin
Zhang, Yanhong
Zhao, Zhongxiang
Cui, Hui
[J]. PHYTOCHEMISTRY LETTERS, 2021, 44 : 62 - 67

← 1 2 3 4 5 →