Background: The COVID-19 epidemic has had an immeasurable impact on all sectors of society and has led to anxiety, depression, fear and other negative psychological reactions among college students. Therefore, it is imperative to investigate, analyze and intervene in such phenomenon. Subjects and methods: In this study, 2,000 college students from a certain university in Zhejiang province are selected as interviewees. Questionnaires are used to summarize and analyze the psychological problems of this group. Besides, statistical methods are conducted to compare the actual effects of different treatments on college students with psychological diseases, so as to find the most appropriate way to alleviate their symptoms. Results: Statistical analysis shows that the main psychological problems affecting college students during the epidemic are anxiety and depression, which account for far more than other possible psychological symptoms. The results of SCL-90 scale test shows that Physical Exercise has the most significant effect (R = 67), while Painting Therapy has the highest stability (sigma = 11.898), compared with the mainstream psychotherapy. Conclusions: The efficacy and stability of different therapies are different. Therefore, when choosing treatment methods, therapists need to analyze both the validity and stability, and consider whether the therapy is easy to operate into practice. The idea of conducting multiple therapies comprehensively deserves further study.