Heart Failure and Adipose Mesenchymal Stem Cells

被引：8
|
作者：
Matsushita, Kenichi [1 ]
机构：
[1] Kyorin Univ, Div Cardiol, Sch Med, Dept Internal Med 2, Tokyo, Japan
来源：
TRENDS IN MOLECULAR MEDICINE | 2020年 / 26卷 / 04期
基金：
日本学术振兴会;
关键词：
PRESERVED EJECTION FRACTION; RENIN-ANGIOTENSIN SYSTEM; II TYPE-2 RECEPTOR; STROMAL CELLS; REGENERATIVE CELLS; ISCHEMIC-HEART; PARACRINE MECHANISMS; CARDIOVASCULAR RISK; BARIATRIC SURGERY; CARDIAC REPAIR;
D O I：
10.1016/j.molmed.2020.01.003
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Mesenchymal stem cells (MSCs) are considered a promising cell type for the treatment of heart failure (HF). In particular, MSCs in adipose tissue are being evaluated as an effective therapeutic tool. However, adipose MSCs are a major source of adipocyte generation and linked to obesity, which is an independent risk factor for HF. MSCs express all of the components of the renin–angiotensin system (RAS), which plays a pivotal role in the pathophysiology of HF. The local RAS also regulates MSC adipogenesis, indicating a connection between MSC–adipogenesis–obesity and HF. This review examines evidence of the complex relationship between HF and adipose MSCs and discusses how to explore this association for favorable therapeutic outcomes for HF. © 2020 Elsevier Ltd
引用
收藏
页码：369 / 379
页数：11
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