CXCL14 expression and potential function in pancreatic cancer

被引：80
|
作者：
Wente, Moritz N. [1 ]
Mayer, Christine [1 ]
Gaida, Matthias M. [1 ]
Michalski, Christoph W. [1 ,2 ]
Giese, Thomas [3 ]
Bergmann, Frank [4 ]
Giese, Nathalia A. [1 ]
Buechler, Markus W. [1 ]
Friess, Helmut [1 ,2 ]
机构：
[1] Heidelberg Univ, Dept Surg, D-69120 Heidelberg, Germany
[2] Tech Univ Munich, Dept Surg, D-81675 Munich, Germany
[3] Heidelberg Univ, Inst Immunol, D-69120 Heidelberg, Germany
[4] Heidelberg Univ, Inst Pathol, D-69120 Heidelberg, Germany
来源：
CANCER LETTERS | 2008年 / 259卷 / 02期
关键词：
pancreatic cancer; CXC chemokines; CXCL14; invasion;
D O I：
10.1016/j.canlet.2007.10.021
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
CXC chemokines influence angiogenesis, growth, and metastatic potential of pancreatic cancer. Therefore, the expression and potential function of CXCL 14, a recently described CXC chemokine, was evaluated. CXCL 14 is upregulated in pancreatic cancer tissues compared to chronic pancreatitis and normal pancreas. Immunolocalization revealed a distinct expression of CXCL14 in tubular complexes in chronic pancreatitis and in particular at the invasive front of pancreatic cancer tissues. Stimulation of pancreatic cancer cells with CXCL14 showed no effects on cell viability and on chemosensitivity. However, CXCL14 clearly increased invasiveness of pancreatic cancer cells without affecting MMP-2 and VEGF secretion, whereas CXCL14 influenced NFkB p65 levels. In conclusion, CXCL14 might play a pivotal role in the pathobiology of pancreatic cancer, probably by regulating cancer invasion. (C) 2007 Elsevier Ireland Ltd. All rights reserved.
引用
收藏
页码：209 / 217
页数：9
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