Mechanisms of allergen-specific immunotherapy for allergic rhinitis and food allergies

被引：34

作者：

Lam, Hiu Yan ^{[1
,2
]}

Tergaonkar, Vinay ^{[1
,2
,3
]}

Ahn, Kwang Seok ^{[4
]}

机构：

[1] Inst Mol & Cell Biol IMCB, Lab NF kB Signaling, 61 Biopolis Dr, Singapore 138673, Singapore

[2] Natl Univ Singapore NUS, Yong Loo Lin Sch Med, Dept Biochem, Singapore 117596, Singapore

[3] Natl Univ Singapore NUS, Yong Loo Lin Sch Med, Dept Pathol, Singapore 117596, Singapore

[4] Kyung Hee Univ, Dept Sci Korean Med, 24 Kyungheedae Ro, Seoul 02447, South Korea

来源：

BIOSCIENCE REPORTS | 2020年 / 40卷

基金：

新加坡国家研究基金会;

关键词：

GRASS-POLLEN IMMUNOTHERAPY; REGULATORY T-CELLS; PEANUT ORAL IMMUNOTHERAPY; FACTOR-KAPPA-B; INNATE LYMPHOID-CELLS; MUTANT TERT PROMOTER; DENDRITIC CELLS; EGG ALLERGY; PHOSPHOLIPASE A(2); IGG ANTIBODIES;

D O I：

10.1042/BSR20200256

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Allergen-specific immunotherapy (AIT) is currently the only potential treatment for allergies including allergic rhinitis (AR) and food allergies (FA) that can modify the underlying course of the diseases. Although AIT has been performed for over a century, the precise and detailed mechanism for AIT is still unclear. Previous clinical trials have reported that successful AIT induces the reinstatement of tolerance against the specific allergen. In this review, we aim to provide an updated summary of the knowledge on the underlying mechanisms of IgE-mediated AR and FA as well as the immunological changes observed after AIT and discuss on how better understanding of these can lead to possible identification of biomarkers and novel strategies for AIT.

引用

页数：19

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