Metal-free, aerobic ketooxygenation of alkenes using hydroxamic acids

被引：49
|
作者：
Schmidt, Valerie A. [1 ]
Alexanian, Erik J. [1 ]
机构：
[1] Univ N Carolina, Dept Chem, Chapel Hill, NC 27599 USA
来源：
CHEMICAL SCIENCE | 2012年 / 3卷 / 05期
关键词：
CATALYZED OXIDATIVE TRANSFORMATION; RUO4-CATALYZED KETOHYDROXYLATION; ALPHA-DIKETONES; PERACETIC-ACID; KETONES; REDUCTION; DIOXYGENATION; HYDROXYLATION; OXYGENATION; DERIVATIVES;
D O I：
10.1039/c2sc01042a
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
A metal-free, radical-mediated alkene ketooxygenation is described. This four-electron alkene oxidation delivers alpha-oxyketones directly from simple alkenes with high levels of regio- and stereocontrol. The aerobic process capitalizes on the unique reactivity of amidoxyl radicals in intra- and intermolecular alkene additions.
引用
收藏
页码：1672 / 1674
页数：3
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