GSK3 TIPping Off p53 to Unleash PUMA

被引：2
|
作者：
Bock, Florian J. [1 ]
Villunger, Andreas [1 ]
机构：
[1] Innsbruck Med Univ, Div Dev Immunol, Bioctr, Innsbruck, Austria
来源：
MOLECULAR CELL | 2011年 / 42卷 / 05期
关键词：
TUMOR SUPPRESSION; APOPTOSIS; TRANSCRIPTION; ACETYLATION; MCL-1;
D O I：
10.1016/j.molcel.2011.05.022
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Knowledge about "life vs. death" decisions made by p53 after DNA damage is limited but critical to preventing side effects during therapeutic application and to improve anticancer activity. Here, Charvet et al. define a signaling network that explains the protective effects of cytokines on cells exposed to gamma-radiation.
引用
收藏
页码：555 / 556
页数：2
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