Two New Prenylated Xanthones from the Pericarp of Garcinia mangostana (Mangosteen)

Two new prenylated xanthones (=9H-xanthen-9-ones), garcimangosxanthones D (1) and E (2), together with the six known xanthones 38, were isolated from the pericarp of Garcinia mangostana. Their structures were determined by analysis of their spectroscopic data. All of the isolated compounds were biologically evaluated for their in vitro cytotoxic activity against A549, Hep-G2, and MCF-7 human-cancer cell lines and antioxidant activity. Compound 1 exhibited moderate cytotoxicity against Hep-G2 (IC50=19.2 mu M) and weak cytotoxicity against MCF-7 (IC50=62.8 mu M) cell lines, and compound 2 showed moderate cytotoxicity against A549, Hep-G2, and MCF-7 cell lines with IC50 values of 12.520.0 mu M (Table 2). Both compounds 1 and 2 demonstrated a weak antioxidant activity with ferric reducing antioxidant power (FRAP) values of 41 +/- 7 and 130 +/- 4 mu mol/g, respectively (Table 3).