Risk Predictors of Advanced Fibrosis in Non-Alcoholic Fatty Liver Disease

被引:1
|
作者
Olteanu, Vasile-Andrei [1 ,2 ]
Balan, Gheorghe G. [1 ,2 ]
Timofte, Oana [1 ,2 ]
Dascalu, Cristina Gena [3 ]
Gologan, Elena [1 ]
Gilca-Blanariu, Georgiana-Emanuela [1 ,2 ]
Diac, Madalina-Maria [4 ,5 ]
Sandu, Ion [6 ,7 ]
Stefanescu, Gabriela [1 ,2 ]
机构
[1] Gr T Popa Univ Med & Pharm, Gastroenterol Dept, 16 Univ St, Iasi 700115, Romania
[2] St 1 Spiridon Emergency Cty Hosp, Inst Gastroenterol & Hepatol, 1 Independentei Blvd, Iasi 700111, Romania
[3] Gr T Popa Univ Med & Pharm, Dept Med Informat, 16 Univ St, Iasi 700115, Romania
[4] Gr T Popa Univ Med & Pharm, Forens Sci Dept, 16 Univ St, Iasi 700115, Romania
[5] Inst Legal Med Iasi, Iasi 700455, Romania
[6] Alexandru Ioan Cuza Univ, Interdisciplinary Res Inst, Sci Dept, 11 Carol I Blvd, Iasi 700506, Romania
[7] Acad Romanian Scientists AORS, 54 Splaiul Independentei St,Sect 5, Bucharest 050094, Romania
关键词
non-alcoholic fatty liver disease; advanced liver fibrosis; 2D shear wave elastography; NONINVASIVE DIAGNOSIS; SCORING SYSTEMS; ULTRASOUND; MORTALITY;
D O I
10.3390/diagnostics12092136
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
The assessment of fibrosis in chronic liver diseases using non-invasive methods is an important topic in hepatology. The aim of this study is to identify patients with non-alcoholic fatty liver disease (NAFLD) and advanced liver fibrosis by establishing correlations between biological/ultrasound markers and non-invasively measured liver stiffness. This study enrolled 116 patients with non-alcoholic fatty liver disease, which were evaluated clinically, biologically, and by ultrasound. Liver fibrosis was quantified by measuring liver stiffness by shear wave elastography (SWE). Multiple correlation analysis of predictors of liver fibrosis identified a number of clinical, biological, and ultrasound parameters (BMI, blood glucose, albumin, platelet count, portal vein diameter, bipolar spleen diameter) that are associated with advanced liver fibrosis in patients with non-alcoholic fatty liver disease. The correlations between the degree of liver fibrosis and the risk values of some serological and ultrasound markers obtained in our study could be useful in clinical practice for the identification of advanced fibrosis in patients with NAFLD.
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页数:12
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