Study on the Antifatigue Effect of Compound Amino Acid Capsules

被引：0
|
作者：
Huang, Wen [1 ]
Hui, Huaqiang [2 ]
Xu, Jiping [1 ]
Guo, Honglei [1 ]
Wang, Yunfeng [1 ]
Zhu, Wei [1 ]
机构：
[1] Changhai Hosp, Internal Med Teaching & Res Off, Changhai, Peoples R China
[2] Xinjiang Urumqi Gen Hosp, Dept Gastroenterol, Urumqi, Peoples R China
来源：
CELLULAR MICROBIOLOGY | 2022年 / 2022卷
关键词：
ANTI-FATIGUE; IN-VITRO; ANTIOXIDANT; EXTRACT; WELL; VIVO;
D O I：
10.1155/2022/6593811
中图分类号：
Q2 [细胞生物学];
学科分类号：
071009 ; 090102 ;
摘要：
Supplementing amino acids was proven to relieve fatigue caused by exercise. This study explored the antifatigue effects of compound amino acid capsules (CAAC) on rats undergoing the forced swimming test (FST). CAAC augmented the endurance of FST in rats and alleviated the damage of skeletal muscle tissue and reduced the content of biochemical indicators in the serum. Furthermore, CAAC prevented skeletal muscle dysfunction in FST rats by modulating inflammation and oxidation reactions. After the treatment with CAAC, apoptosis and apoptosis-related protein and p-p65 were weakened, while the levels of SIRT1 and SIRT1/PGC-1 alpha /Nrf2 pathway-related proteins were enhanced. The antifatigue properties of CAAC were associated with its antioxidant and anti-inflammatory capabilities, which were realized by activating the SIRT1/PGC-1 alpha /Nrf2 pathway.
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页数：10
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