Characterization of the Antinociceptive Activity from Stevia serrata Cav

被引:7
|
作者
Cordeiro, Millena S. [1 ]
Simas, Daniel L. R. [2 ]
Perez-Sabino, Juan E. [3 ]
Merida-Reyes, Max S. [3 ]
Munoz-Wug, Manuel A. [3 ]
Oliva-Hernandez, Bessie E. [3 ]
da Silva, Antonio J. R. [2 ]
Fernandes, Patricia D. [1 ]
Giorno, Thais B. S. [1 ]
机构
[1] Univ Fed Rio de Janeiro, Inst Biomed Sci, BR-21941902 Rio De Janeiro, Brazil
[2] Univ Fed Rio de Janeiro, Inst Nat Prod Res, BR-21941902 Rio De Janeiro, Brazil
[3] Univ San Carlos, Fac Chem Sci & Pharm, Sch Chem, Guatemala City 01012, Guatemala
关键词
Stevia serrata; essential oil; inflammation; antinociception; pain; RECUTITA L. RAUSCHERT; ANTIINFLAMMATORY ACTIVITY; ESSENTIAL OIL; CAPSAICIN; GLUTAMATE; INVOLVEMENT; MECHANISMS; RECEPTORS; RESPONSES; MOUSE;
D O I
10.3390/biomedicines8040079
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
Background: Stevia serrata Cav. (Asteraceae), widely found in Guatemala, is used to treat gastrointestinal problems. The aim of this study was to demonstrate the antinociceptive and anti-inflammatory effects of the essential oil (EO) and the mechanism of action. Methods: EO was tested in chemical (capsaicin- and glutamate-induced licking response) or thermal (hot plate) models of nociception at 10, 30 or 100 mg/kg doses. The mechanism of action was evaluated using two receptor antagonists (naloxone, atropine) and an enzyme inhibitor (L-NAME). The anti-hyperalgesic effect was evaluated using carrageenan-induced nociception and evaluated in the hot plate. Results: All three doses of EO reduced licking response induced by glutamate, and higher doses reduced capsaicin-induced licking. EO also increased area under the curve, similar to the morphine-treated group. The antinociceptive effect induced by EO was reversed by pretreatment of mice with naloxone (1 mg/kg, ip), atropine (1 mg/kg, ip) or L-NAME (3 mg/kg, ip). EO also demonstrated an anti-hyperalgesic effect. The 100 mg/kg dose increased the latency time, even at 1 h after oral administration and this effect has been maintained until the 96th hour, post-administration. Conclusions: Our data suggest that essential oil of S. serrata presents an antinociceptive effect mediated, at least in part, through activation of opioid, cholinergic and nitrergic pathways.
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页数:10
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