1,4-Dipolar Cycloaddition Reactions in Ionic Liquids: A Facile Synthesis of 9aH,15H-[1]Benzopyrano[3′,2′:3,4]pyrido[2,1-a]isoquinolines (=9aH,15H-Benzo[a][1]benzopyrano[2,3-h]quinolizines)

被引：6

作者：

Reddy, Basi V. Subba ^{[1
]}

Yadav, Nagendra Nath ^{[1
]}

Srivastava, Nikhil ^{[1
]}

Yadav, Jhillu S. ^{[1
]}

Sridhar, Balasubramanian ^{[2
]}

机构：

[1] Indian Inst Chem Technol, Organ Chem Div 1, Hyderabad 500007, Andhra Pradesh, India

[2] Indian Inst Chem Technol, Ctr Xray Crystallog, Hyderabad 500007, Andhra Pradesh, India

来源：

HELVETICA CHIMICA ACTA | 2012年 / 95卷 / 01期

关键词：

1]Benzopyranopyrido-isoquinolines; Benzo-[1]benzopyrano-quinolizines; Cycloadditions; X-Ray crystallography; Ionic liquids; Multicomponent reactions; QUINOLINE-DMAD ZWITTERION; DIMETHYL ACETYLENEDICARBOXYLATE; MULTICOMPONENT REACTIONS; EFFICIENT SYNTHESIS; ENANTIOSELECTIVE ADDITION; STEREOSELECTIVE-SYNTHESIS; ACTIVATED ACETYLENES; N-HETEROCYCLES; ISOQUINOLINE; CONSTRUCTION;

D O I：

10.1002/hlca.201100250

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Ionic liquids were found to be a suitable reaction medium for 1,4-dipolar cycloaddition reactions of an isoquinoline, an activated alkyne, and a 4-oxo-4H-1-benzopyran-3-carboxaldehyde at room temperature to afford [1]benzopyrano-pyrido-isoquinoline (=9aH,15H-benzo[a][1]benzopyrano[2,3-h]quinolizine) derivatives selectively in good yields. The ionic liquid can be recovered and recycled in further runs without loss of activity.

引用

页码：76 / 86

页数：11

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