Intravitreal Foscarnet for the Treatment of Acyclovir-resistant Acute Retinal Necrosis Caused by Varicella Zoster Virus

被引：23
|
作者：
Lee, Mee Yon [1 ]
Kim, Kyu Seop [1 ]
Lee, Won Ki [1 ]
机构：
[1] Catholic Univ Korea, Coll Med, Seoul St Marys Hosp, Dept Ophthalmol, Seoul 137701, South Korea
来源：
OCULAR IMMUNOLOGY AND INFLAMMATION | 2011年 / 19卷 / 03期
关键词：
acute renal failure; acute retinal necrosis; acyclovir; intravitreal foscarnet; varicella zoster virus; MANAGEMENT; INJECTIONS;
D O I：
10.3109/09273948.2010.544857
中图分类号：
R77 [眼科学];
学科分类号：
100212 ;
摘要：
Purpose: To report of a case of acute retinal necrosis (ARN), successfully treated with intravitreal foscarnet. Methods: Case report. Results: A 40-year-old man diagnosed with varicella zoster virus (VZV)-induced ARN failed standard acyclovir treatment. He was treated subsequently with intravenous foscarnet, but developed acute renal failure after 1 day of treatment. All systemic anti-viral agents were discontinued, and intravitreal foscarnet was administered weekly. After 5 injections, the retinitis was dramatically improved. Conclusions: Intravitreal foscarnet was efficacious in the treatment of acyclovir-resistant ARN caused by VZV. It may be used as the sole treatment in patients with intolerance to systemic administration.
引用
收藏
页码：212 / 213
页数：2
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