Scalable in Situ Diazomethane Generation in Continuous-Flow Reactors

被引：59

作者：

Rossi, Emiliano ^{[2
]}

Woehl, Pierre ^{[1
]}

Maggini, Michele ^{[2
]}

机构：

[1] Univ Padua, Dept Chem Sci, I-35131 Padua, Italy

[2] Corning European Technol Ctr, F-77210 Avon, France

来源：

ORGANIC PROCESS RESEARCH & DEVELOPMENT | 2012年 / 16卷 / 05期

关键词：

D O I：

10.1021/op200110a

中图分类号：

O69 [应用化学];

学科分类号：

081704 ;

摘要：

Diazomethane is a valuable derivatizing agent but very difficult to handle for large-scale chemical transformations. We report here the base-induced decomposition of N-methyl-N-nitrosourea under continuous-flow conditions that enables the production up to 19 mol d(-1) of diazomethane, at a total flow rate of 53 mL min(-1).

引用

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页码：1146 / 1149

页数：4

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