Development of the first sphingomyelin biomimetic stationary phase for immobilized artificial membrane (IAM) chromatography

被引：24
|
作者：
Verzele, Dieter [1 ]
Lynen, Frederic [1 ]
De Vrieze, Mike [1 ]
Wright, Adrian G. [2 ]
Hanna-Brown, Melissa [2 ]
Sandra, Pat [1 ,3 ]
机构：
[1] Univ Ghent, Pfizer Analyt Res Ctr, Dept Organ Chem, B-9000 Ghent, Belgium
[2] Pfizer Global R&D Labs, Analyt Dev, Sandwich CT13 9NJ, Kent, England
[3] Res Inst Chromatog, B-8500 Kortrijk, Belgium
来源：
CHEMICAL COMMUNICATIONS | 2012年 / 48卷 / 08期
关键词：
PERFORMANCE LIQUID-CHROMATOGRAPHY; SOLID-PHASE; COLUMN; LIPIDS; MODEL;
D O I：
10.1039/c2cc16872c
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
A prototype sphingomyelin stationary phase for Immobilized Artificial Membrane (IAM) chromatography was synthesized by an ultra-short, solid-phase inspired methodology, in which an oxidative release monitoring strategy played a vital role. Evaluated in a proof-of-concept model for blood-brain barrier passage, partial least squares regression demonstrated its potential as an in vitro prediction tool.
引用
收藏
页码：1162 / 1164
页数：3
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