The neuropsychological spectrum of anti-LGI1 antibody mediated autoimmune encephalitis

被引:24
|
作者
Griffith, Sarah P. [1 ,2 ]
Malpas, Charles B. [1 ,2 ,3 ,4 ]
Alpitsis, Rubina [1 ,2 ]
O'Brien, Terence J. [1 ,2 ,3 ,4 ]
Monif, Mastura [1 ,2 ,3 ]
机构
[1] Monash Univ, Fac Med Nursing & Hlth Sci, Cent Clin Sch, Dept Neurosci, Melbourne, Vic, Australia
[2] Alfred Hlth, Dept Neurol, Melbourne, Vic, Australia
[3] Melbourne Hlth, Dept Neurol, Parkville, Vic, Australia
[4] Royal Melbourne Hosp, Dept Med, Parkville, Vic, Australia
关键词
Autoimmune Diseases; Neuroimmunology; Autoimmune Encephalitis; Limbic Encephalitis; Anti-LGI1; Encephalitis; LGI1; Neuropsychology; Cognitive Assessment; LIMBIC ENCEPHALITIS; HIPPOCAMPAL SUBFIELDS; MEMORY DEFICITS; LGI1; IMPAIRMENT; ATROPHY;
D O I
10.1016/j.jneuroim.2020.577271
中图分类号
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号
100102 ;
摘要
Anti-Leucine Glioma Inactivated 1 (LGI-1) autoimmune encephalitis (AE) is a rare neuroinflammatory brain condition. Individuals afflicted with this condition can present with cognitive and psychological manifestations that can impact the individual's quality of life, day to day functioning, independence, return to work and interpersonal relationships. Our knowledge of the cognitive profiles and disease associated psychopathology is severely lacking. This review provides a comprehensive summary of the currently available literature, conceptualising our current understanding of the neuropsychological manifestations of anti LGI-1 AE and summarises methodological limitations of the current research to inform and improve future investigations.
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收藏
页数:8
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