Pre- versus post-column oxidation liquid chromatography fluorescence detection of paralytic shellfish toxins

被引：25
|
作者：
DeGrasse, Stacey L. [1 ]
van de Riet, Jeffrey [2 ]
Hatfield, Robert [3 ]
Turner, Andrew [3 ]
机构：
[1] US FDA, Ctr Food Safety & Appl Nutr, Off Regulatory Sci, Div Analyt Chem,Spect & Mass Spectrometry Branch, College Pk, MD 20740 USA
[2] Canadian Food Inspect Agcy, Dartmouth Lab, Dartmouth, NS B3B 1Y9, Canada
[3] Ctr Environm Fisheries & Aquaculture Sci, Weymouth DT4 8UB, Dorset, England
来源：
TOXICON | 2011年 / 57卷 / 04期
关键词：
LC; Oxidation; Paralytic shellfish toxins; Saxitoxin; Validation; POISONING TOXINS; PRECHROMATOGRAPHIC OXIDATION; QUANTITATIVE-DETERMINATION; ALEXANDRIUM; GULF; MUSSELS; OYSTERS; CLAMS; PSP;
D O I：
10.1016/j.toxicon.2010.12.017
中图分类号：
R9 [药学];
学科分类号：
1007 ;
摘要：
Both pre- and post-column oxidation liquid chromatography methods with fluorescence detection are available for detecting paralytic shellfish toxins. Each method has been evaluated in multiple laboratories and validated as a potential alternative to the mouse bioassay. This communication compares the advantages and limitations of both methods. For a given laboratory, the selection of either method may be based primarily on practicality and less on any deficiencies in scientific merit. Published by Elsevier Ltd.
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页码：619 / 624
页数：6
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