Single-Molecule Detection of Proteins Using Aptamer-Functionalized Molecular Electronic Devices

被引：98

作者：

Liu, Song ^{[1
]}

Zhang, Xinyue ^{[2
]}

Luo, Wangxi ^{[2
]}

Wang, Zhenxing ^{[1
]}

Guo, Xuefeng ^{[1
]}

Steigerwald, Michael L. ^{[3
,4
]}

Fang, Xiaohong ^{[2
]}

机构：

[1] Peking Univ, Coll Chem & Mol Engn, State Key Lab Struct Chem Unstable & Stable Speci, Beijing Natl Lab Mol Sci, Beijing 100871, Peoples R China

[2] Chinese Acad Sci, Inst Chem, Beijing Natl Lab Mol Sci, Beijing 100190, Peoples R China

[3] Dept Chem, New York, NY USA

[4] Columbia Univ, Ctr Elect Mol Nanostruct, New York, NY USA

来源：

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | 2011年 / 50卷 / 11期

关键词：

aptamers; biosensors; molecular devices; nanotubes; PROSTATE-SPECIFIC ANTIGEN; LABEL-FREE; ELECTRICAL DETECTION; CARBON NANOTUBES; REAL-TIME; DNA; THROMBIN; FABRICATION; ANTIBODY; BIOLOGY;

D O I：

10.1002/anie.201006469

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Filling in the gap: Label-free, real-time electrical detection of proteins is achieved with high selectivity and real single-molecule sensitivity by using aptamer-functionalized molecular electronic devices with single-walled carbon nanotubes as point contacts. Copyright © 2011 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

引用

页码：2496 / 2502

页数：7

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