Stem Cell-Mediated Delivery of Therapies in the Treatment of Glioma

被引：5
|
作者：
Frosina, G. [1 ]
机构：
[1] Ist Nazl Ric Canc, Mol Mutagenesis & DNA Repair Unit, I-16132 Genoa, Italy
来源：
MINI-REVIEWS IN MEDICINAL CHEMISTRY | 2011年 / 11卷 / 07期
关键词：
Glioma; stem; gene therapy; cancer; resistance; NEURAL PROGENITOR CELLS; STROMAL CELLS; GENE-THERAPY; MIGRATION; TROPISM; BRAIN; GROWTH;
D O I：
10.2174/138955711795906897
中图分类号：
R914 [药物化学];
学科分类号：
100701 ;
摘要：
High grade gliomas can be seldom controlled, due to the infiltrative nature of these tumors and the presence of cell populations resistant to radio- and chemotherapy. Current research aims to develop novel therapeutic approaches to track and eliminate the disseminated glioma-driving cells. Selected delivery of therapeutic agents taking advantage of the tropism of normal stem cells for glioma cells might be one.
引用
收藏
页码：591 / 598
页数：8
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