HPLC-MS/MS analysis of ilimaquinone and its application in a pharmacokinetic study in rats

被引：11
|
作者：
Son, Heebin [1 ]
Noh, Keumhan [2 ]
Kang, Changhyun [1 ]
Na, MinKyun [3 ]
Oh, Sangtaek [4 ]
Song, Im-Sook [5 ,6 ]
Kang, Wonku [1 ]
机构：
[1] Chung Ang Univ, Coll Pharm, Seoul 06974, South Korea
[2] Univ Toronto, Dept Pharmaceut Sci, Leslie & Fac Pharm, 144 Coll St, Toronto, ON, Canada
[3] Chungnam Natl Univ, Coll Pharm, Daejeon 34134, South Korea
[4] Kookmin Univ, Dept Bio & Fermentat Convergence Technol, Seoul 02707, South Korea
[5] Kyungpook Natl Univ, Coll Pharm, Daegu 41566, South Korea
[6] Kyungpook Natl Univ, Res Inst Pharmaceut Sci, Daegu 41566, South Korea
来源：
JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS | 2019年 / 166卷
基金：
新加坡国家研究基金会;
关键词：
Ilimaquinone; LC-MS/MS; Rat plasma; Stability; GAP JUNCTIONAL COMMUNICATION; MARINE SPONGE METABOLITES; ETHYLSMENOQUINONE; ACTIVATION; APOPTOSIS; CELLS;
D O I：
10.1016/j.jpba.2019.01.030
中图分类号：
O65 [分析化学];
学科分类号：
070302 ; 081704 ;
摘要：
Ilimaquinone, a metabolite isolated from the marine sponge Hippiospongia metachromia, has antimicrobial, cytotoxic, anti-HIV, anti-inflammatory, and anti-cancer activities. A new quantitative analytical method for determination of ilimaquinone in rat plasma using HPLC-MS/MS was developed and validated. Ascorbic acid was added to ensure the stability of ilimaquinone in plasma. After protein precipitation using acetonitrile plus diclofenac as an internal standard, the analytes were chromatographed on a biphenyl column with a mobile phase of methanol and water (8:2, v/v, including 0.1% formic acid). This method was successfully applied in a pharmacokinetic study of ilimaquinone after oral administration in rats. (C) 2019 Elsevier B.V. All rights reserved.
引用
收藏
页码：291 / 294
页数：4
相关论文
共 50 条
  • [1] HPLC-MS/MS analysis of mesupron and its application to a pharmacokinetic study in rats
    Park, Changmin
    Ha, Joong Gyu
    Choi, Seungmok
    Kim, Eunyoung
    Noh, Keumhari
    Shin, Beom Soo
    Kang, Wonku
    [J]. JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS, 2018, 150 : 39 - 42
  • [2] Quantitative analysis of eletriptan in human plasma by HPLC-MS/MS and its application to pharmacokinetic study
    Ponnuru, Venkata Suresh
    Challa, B. R.
    Nadendla, Ramarao
    [J]. ANALYTICAL AND BIOANALYTICAL CHEMISTRY, 2011, 401 (08) : 2539 - 2548
  • [3] Quantitative analysis of eletriptan in human plasma by HPLC-MS/MS and its application to pharmacokinetic study
    Venkata Suresh Ponnuru
    B. R. Challa
    Ramarao Nadendla
    [J]. Analytical and Bioanalytical Chemistry, 2011, 401 : 2539 - 2548
  • [4] Determination of panduratin A in rat plasma by HPLC-MS/MS and its application to a pharmacokinetic study
    Kim, Minsoo
    Choi, Seungmok
    Noh, Keumhan
    Kim, Changhee
    Kim, Eunyoung
    Hwang, Jae-Kwan
    Kang, Wonku
    [J]. JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS, 2017, 137 : 151 - 154
  • [5] Quantitative determination of xanthorrhizol in rat plasma by HPLC-MS/MS and its application to a pharmacokinetic study
    Choi, Seungmok
    Kim, Minsoo
    Kim, Changhee
    Hwang, Jae-Kwan
    Kang, Wonku
    [J]. JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS, 2017, 132 : 56 - 59
  • [6] Quantitative determination of bilobetin in rat plasma by HPLC-MS/MS and its application to a pharmacokinetic study
    Son, Heebin
    Kang, Wonku
    [J]. BIOMEDICAL CHROMATOGRAPHY, 2020, 34 (04)
  • [7] Pharmacokinetic Study of Swertisin by HPLC-MS/MS After Intravenous Administration in Rats
    Li, Yaxin
    Zhao, Xiaotong
    Zhang, Yanqing
    Xie, Junbo
    Zhang, Kunsheng
    Zhou, Aimin
    [J]. JOURNAL OF CHROMATOGRAPHIC SCIENCE, 2017, 55 (01) : 40 - +
  • [8] Pharmacokinetic study of deufruquintinibs in rats by HPLC-MS/MS after oral administration
    Hu, Junfeng
    Liu, Wei
    Wang, Ying
    Chen, Xin
    Guo, Yanwei
    Peng, Qianqian
    Guo, Jian
    Zhang, Hongqi
    Zhang, Shizhong
    Deng, Gaigai
    [J]. BIOMEDICAL CHROMATOGRAPHY, 2022, 36 (11)
  • [9] Simultaneous quantification of volitinib and gefitinib in rat plasma by HPLC-MS/MS for application to a pharmacokinetic study in rats
    Noh, Chi-Kyoung
    Lee, Jong-Hwa
    Kim, Min-Soo
    Maeng, Han-Joo
    Chung, Suk-Jae
    [J]. JOURNAL OF SEPARATION SCIENCE, 2017, 40 (19) : 3782 - 3791
  • [10] An HPLC-MS/MS method for quantitation of trelagliptin and application in a comparative pharmacokinetic study
    Han, Ying
    Chen, Liqing
    Liu, Wei
    Xin, Xin
    Meng, Lingwei
    Chu, Xiaoyang
    Huang, Wei
    Jin, Mingji
    Gao, Zhonggao
    [J]. BIOANALYSIS, 2019, 11 (19) : 1755 - 1765
12345