Development of a novel ionic support and its application in the ionic liquid phase assisted synthesis of a potent antithrombotic

被引：42
|
作者：
de Kort, M
Tuin, AW
Kuiper, S
Overkleeft, HS
van der Marel, GA
Buijsman, RC
机构：
[1] NV Organon, Lead Discovery Unit, NL-5340 BH Oss, Netherlands
[2] Leiden Univ, Leiden Inst Chem, Gorlaeus Labs, NL-2300 RA Leiden, Netherlands
来源：
TETRAHEDRON LETTERS | 2004年 / 45卷 / 10期
关键词：
ionic liquid; supported chemistry; sulfonamide; multistep synthesis Tirofiban;
D O I：
10.1016/j.tetlet.2004.01.032
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
The synthesis of ironic support 1 and its application in the preparation of a set of amides and sulforamides is described. The potential of 1 is further exemplified by its use in a one-pot multistep ionic liquid phase assisted synthesis of tirofiban analogue 2. (C) 2001 Elsevier Ltd. All rights reserved.
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收藏
页码：2171 / 2175
页数：5
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