Introduction. The development of an innovation-based competitive and highly structured model of the Ukrai-nian economy is impossible without modern advanced industry. Problem Statement. To launch structural and technological transformations, Ukraine needs to implement a systematic, consistent innovative industrial policy aiming at neo-industrialization as a basis for developing the domestic market, increasing exports of goods with a high added value, improving the quality of life, reducing poverty, and forming the middle class of society. Purpose. To determine the current trends in the innovative processes in Ukraine's industry by technology-in-tensive sectors from the standpoint of opportunities and threats for the neo-industrial development of Ukraine. Materials and Methods. The research is based on the Neo-Schumpeterian school and institutional theory and on the theoretical achievements of Ukrainian and foreign researchers on innovation and the implementation of structural and technological shifts in the economy. The methods of analysis and synthesis, logical generalization, system approach, and statistical analysis have been used. Results. The institutional foundations for the modernization and development of Ukrainian industry in ac-cordance with the modern world trends has been found underdeveloped. The innovative activities of industries in terms of costs and benefits, which are systematized according to the levels of manufacturability based on the Eurostat methodology have been analyzed. Unstable dynamics and a significant difference between technology-intensive sectors, a decrease in the knowledge intensity of innovation products, a low efficiency of investment in innovation in most industries, and a tendency towards simplifying the innovative activities in the industry have been revealed. Conclusion. The proposed directions and measures of innovation-based industrial policy are to facilitate neo-industrialization of Ukraine and to overcome its innovative and technological decline.