HMGB1 expression in urothelial carcinoma of the bladder

被引:1
|
作者
Suren, Dinc [1 ]
Yildirim, Hulya Tosun [1 ]
Atalay, Irem [1 ]
Sayiner, Alper [1 ]
Yildirim, Mustafa [2 ]
Alikanoglu, Arsenal Sezgin [1 ]
Sezer, Cem [1 ]
机构
[1] Univ Hlth Sci, Antalya Educ & Res Hosp, Dept Pathol, Kazim Karabekir St, TR-07050 Antalya, Turkey
[2] Med Pk Hosp, Dept Med Oncol, Gaziantep, Turkey
来源
JOURNAL OF BUON | 2018年 / 23卷 / 06期
关键词
bladder neoplasms; diagnostic use; HMGB1; protein; pathology; prognosis; BACILLUS-CALMETTE-GUERIN; GROUP BOX 1; SQUAMOUS-CELL CARCINOMA; MOBILITY GROUP BOX-1; POOR-PROGNOSIS; CANCER CELLS; PROGRESSION; INTERFERON-ALPHA-2B; OVEREXPRESSION; PROTEINS;
D O I
暂无
中图分类号
R73 [肿瘤学];
学科分类号
100214 ;
摘要
Purpose: HMGB1, the most important member of the high mobility group box protein family, is a nuclear protein with different functions in the cell; it has a role in cancer progression, angiogenesis, invasion, and metastasis development. We studied the expression of HMGB1 and whether it is a prognostic factor in urothelial carcinoma of bladder (UCB) or not. Methods: The study included 90 cases that were histopathologically diagnosed with UCB in the tissue samples obtained by transurethral resection (TUR). HMGB1 expression was investigated by immunohistochemistry. Results:A total of 90 patients, 80 (88.9%) male and 10 (11.1%) female, were enrolled in the study. The histopathological diagnosis was infiltrating urothelial carcinoma (IUC) in 63 (70.0%) and non-invasive papillary urothelial carcinoma (NIPUC) in 27 (30.0%). When the NIPUC cases were grouped according to grade, 24 (88.9%) of the cases were low grade and 3 (11.1%) were high grade. HMGB1 expression was found positive in 51 (56.796) and negative in 39 (43.3%) of the patients. HMGB1 expression was significantly higher in IUCs (p=0.046). Conclusion: The results of our study demonstrate that HMGB1 overexpression has a significant role in UCB progression and it corroborates the idea that it might be an important prognostic factor.
引用
收藏
页码:1882 / 1886
页数:5
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