Effect of Antioxidant Echinochrome A on Bleomycin-Induced Pulmonary Fibrosis

被引：14
|
作者：
Lebed'ko, O. A. [1 ,2 ]
Ryzhavskii, B. Ya. [2 ]
Demidova, O. V. [2 ]
机构：
[1] Russian Acad Med Sci, Far Eastern Sci Ctr Physiol & Pathol Resp, Res Inst Maternal & Child Welf, Siberian Div,Khabarovsk Div, Khabarovsk, Russia
[2] Far Eastern State Med Univ, Dept Histol, Khabarovsk, Russia
来源：
BULLETIN OF EXPERIMENTAL BIOLOGY AND MEDICINE | 2015年 / 159卷 / 03期
关键词：
bleomycin; pulmonary fibrosis; antioxidant; echinochrome A; HYALURONIDASE; STRESS;
D O I：
10.1007/s10517-015-2960-3
中图分类号：
R-3 [医学研究方法]; R3 [基础医学];
学科分类号：
1001 ;
摘要：
We studied the protective effect of antioxidant echinochrome A on bleomycin-induced pulmonary fi brosis in rats at the early stages of postnatal ontogeny. Administration of echinochrome A was shown to reduce the severity of bleomycin-induced oxidative stress in the lungs, prevented the development of hypertrophy of interalveolar connective tissue and peribronchial lymphoid infi ltration, and normalized the ratio of volume densities of interalveolar septa and alveolar lumen.
引用
收藏
页码：351 / 354
页数：4
相关论文
共 50 条
  • [1] Effect of Antioxidant Echinochrome A on Bleomycin-Induced Pulmonary Fibrosis
    O. A. Lebed’ko
    B. Ya. Ryzhavskii
    O. V. Demidova
    [J]. Bulletin of Experimental Biology and Medicine, 2015, 159 : 351 - 354
  • [2] Echinochrome A Treatment Alleviates Fibrosis and Inflammation in Bleomycin-Induced Scleroderma
    Park, Gyu-Tae
    Yoon, Jung-Won
    Yoo, Sang-Bin
    Song, Young-Chul
    Song, Parkyong
    Kim, Hyoung-Kyu
    Han, Jin
    Bae, Sung-Jin
    Ha, Ki-Tae
    Mishchenko, Natalia P.
    Fedoreyev, Sergey A.
    Stonik, Valentin A.
    Kim, Moon-Bum
    Kim, Jae-Ho
    [J]. MARINE DRUGS, 2021, 19 (05)
  • [3] THE EFFECT OF LIPOPOLYSACCHARIDE ON BLEOMYCIN-INDUCED PULMONARY FIBROSIS
    PHAN, SH
    FANTONE, JC
    MCGARRY, B
    [J]. AMERICAN REVIEW OF RESPIRATORY DISEASE, 1982, 125 (04): : 54 - 54
  • [4] Attenuation of bleomycin-induced pulmonary fibrosis by a catalytic antioxidant metalloporphyrin
    Oury, TD
    Thakker, K
    Menache, M
    Chang, LY
    Crapo, JD
    Day, BJ
    [J]. AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY, 2001, 25 (02) : 164 - 169
  • [5] The Integrin Inhibitor Cilengitide and Bleomycin-Induced Pulmonary Fibrosis Cilengitide and Bleomycin-Induced Pulmonary Fibrosis
    Ritzenthaler, Jeffrey D.
    Zhang, Michael
    Torres-Gonzalez, Edilson
    Roman, Jesse
    [J]. LUNG, 2020, 198 (06) : 947 - 955
  • [6] The Effect Of Influenza Infection On Bleomycin-Induced Pulmonary Fibrosis
    Stavrou, A.
    Jolly, L.
    Habgood, A.
    John, A. E.
    Hussell, T.
    Blanchard, A.
    Jenkins, G. R.
    [J]. AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE, 2013, 187
  • [7] The effect of melatonin on bleomycin-induced pulmonary fibrosis in rats
    Arslan, SO
    Zerin, M
    Vural, H
    Coskun, A
    [J]. JOURNAL OF PINEAL RESEARCH, 2002, 32 (01) : 21 - 25
  • [8] The effect of erythropoietin on bleomycin-induced pulmonary fibrosis in rats
    Tsavlis, Drosos
    Spandou, Evangellia
    Koliakos-Kouzi, Kokkona
    Koutsonikolas, Dimitrios
    Tzoumaka, Anna
    Simeonidou, Constantina
    Angomachalelis, Ioannis
    Bountzioukas, Solon
    [J]. CHEST, 2007, 132 (04) : 582S - 582S
  • [9] Effect of Feitai on bleomycin-induced pulmonary fibrosis in rats
    Gong, LK
    Li, XH
    Wang, H
    Zhang, L
    Chen, FP
    Cai, Y
    Qi, XM
    Liu, LL
    Liu, YZ
    Wu, XF
    Huang, CG
    Ren, J
    [J]. JOURNAL OF ETHNOPHARMACOLOGY, 2005, 96 (03) : 537 - 544
  • [10] The Integrin Inhibitor Cilengitide and Bleomycin-Induced Pulmonary FibrosisCilengitide and Bleomycin-Induced Pulmonary Fibrosis
    Jeffrey D. Ritzenthaler
    Michael Zhang
    Edilson Torres-Gonzalez
    Jesse Roman
    [J]. Lung, 2020, 198 : 947 - 955
12345