Increased expression of interleukin 17 in the cortex and hippocampus from patients with mesial temporal lobe epilepsy

被引：14
|
作者：
He, Jiao-Jiang [1 ]
Sun, Fei-Ji [2 ]
Wang, Yu [1 ]
Luo, Xiao-Qin [3 ]
Lei, Peng [1 ]
Zhou, Jie [1 ]
Zhu, Di [1 ]
Li, Zhi-Yun [1 ]
Yang, Hui [2 ]
机构：
[1] Lanzhou Gen Hosp PLA, Dept Neurosurg, Lanzhou 730050, Peoples R China
[2] Third Mil Med Univ, Xinqiao Hosp, Dept Neurosurg, Chongqing 400037, Peoples R China
[3] Mianzhu Peoples Hosp, Dept Nephrol, Mianzhu 618200, Sichuan, Peoples R China
来源：
JOURNAL OF NEUROIMMUNOLOGY | 2016年 / 298卷
关键词：
Mesial temporal lobe epilepsy; Inflammatory cytokine; Interleukin; 17; BLOOD-BRAIN-BARRIER; ACTIVATION; IL-17; GLUTAMATE; SEIZURE; SYSTEM; CELLS; MALFORMATIONS; CYTOKINES; RECEPTOR;
D O I：
10.1016/j.jneuroim.2016.07.017
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
Mesial temporal lobe epilepsy (MTLE) is the most common form of focal epilepsies in adults and proinflammatory cytokines have long been thought to play an important role in pathogenesis and epileptogenicity. In the present study, we investigated the levels and expression patterns of the interleukin 17 (IL-17) system in temporal neocortex and hippocampus from 24 patients with MTLE and 8 control (Ctr) samples. We found that IL-17 and IL-17 receptor (IL-17R) were clearly upregulated in MTLE at both mRNA and protein levels, compared with Ctr. Immunostaining indicated that neurons, astrocytes, microglia and endothelial cells of blood vessels are the major sources of IL-17. These findings suggest that IL-17 system may be involved in the pathogenesis and epileptogenicity of MTLE. (C) 2016 Published by Elsevier B.V.
引用
收藏
页码：153 / 159
页数：7
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