Atopic dermatitis: recent insight on pathogenesis and novel therapeutic target

被引:37
|
作者
D'Auria, Enza [1 ]
Banderali, Giuseppe [1 ]
Barberi, Salvatore [2 ]
Gualandri, Lorenzo [3 ]
Pietra, Benedetta [1 ]
Riva, Enrica [1 ]
Cerri, Amilcare [3 ]
机构
[1] Univ Milan, Dept Hlth Sci, San Paolo Hosp, Dept Pediat, I-20122 Milan, Italy
[2] Fatebenefratelli Hosp, Dept Pediat, Milan, Italy
[3] Univ Milan, San Paolo Hosp, Dept Hlth Sci, Pediat Dermatol Dermatol Clin, I-20122 Milan, Italy
来源
关键词
atopic dermatitis; skin barrier; skin microbioma; anti-inflammatory therapies; dietary factors; biologics; TOPICAL CALCINEURIN INHIBITORS; SKIN MICROBIOME; EFFICACY; BARRIER; ECZEMA; METAANALYSIS; GUIDELINES; EXPRESSION; MANAGEMENT; MOISTURIZERS;
D O I
10.12932/AP0732.34.2.2016
中图分类号
R392 [医学免疫学];
学科分类号
100102 ;
摘要
Atopic dermatitis (AD) is the most common chronic inflammatory skin disease. It affects infancy, but it is also highly prevalent in adults and it is one of the disease burdens for the patients and their families. Nowadays, AD is recognized as a heterogenous disease with different subtypes with variable clinical manifestations which is affected by the impairments of the skin barrier. The severity of AD dictates the level of treatment. Current AD treatment focuses on restoration of the barrier function, mainly through the use of moisturizers and corticosteroids to control the inflammation, topical calcineurin inhibitors, and immunosuppresive drugs in the most severe cases. However, targeted disease-modifying therapies are under investigation. The most recent findings on the skin microbial dysbiosis is a promising future direction for the development of new treatments. We need to improve the understanding of the complex microbiome-host interactions, the role of autoimmunity, the comparative effectiveness of therapies and the ways to appropriately implement the educational strategies.
引用
收藏
页码:98 / 108
页数:11
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