Synthesis of 2-Aminoindolizines by 1,3-Dipolar Cycloaddition of Pyridinium Ylides with Electron-Deficient Ynamides

被引：122

作者：

Brioche, Julien ^{[1
]}

Meyer, Christophe ^{[1
]}

Cossy, Janine ^{[1
]}

机构：

[1] PSL Res Univ, Lab Chim Organ, Inst Chem Biol & Innovat CBI, ESPCI ParisTech,CNRS UMR8231, F-75231 Paris 05, France

来源：

ORGANIC LETTERS | 2015年 / 17卷 / 11期

关键词：

HIGHLY EFFICIENT SYNTHESIS; ONE-POT SYNTHESIS; FUNCTIONALIZED INDOLIZINES; CATALYZED CYCLIZATION; POLYSUBSTITUTED INDOLIZINES; CONVENIENT SYNTHESIS; C-C; ROUTE; HETEROCYCLES; NITROGEN;

D O I：

10.1021/acs.orglett.5b01205

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Electron-deficient ynamides, possessing an ynoate or an ynone moiety, have been successfully involved for the first time in a 1,3-dipolar cycloaddition with stabilized pyridinium ylides. These reactions afford an efficient and general access toward a variety of substituted 2-aminoindolizines which can serve as useful precursors for the synthesis of other more complex nitrogen heterocycles.

引用

页码：2800 / 2803

页数：4

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