Mannose-binding lectin polymorphisms in clinical tuberculosis

被引:126
|
作者
Soborg, C
Madsen, HO
Andersen, ÅB
Lillebaek, T
Kok-Jensen, A
Garred, P
机构
[1] Rigshosp, Dept Clin Immunol, Tissue Typing Lab 7631, DK-2100 Copenhagen O, Denmark
[2] Rigshosp, Dept Infect Dis, DK-2100 Copenhagen O, Denmark
[3] State Serum Inst, Int Reference Lab Mycobacteriol, Copenhagen, Denmark
[4] Dept Resp Med, Gentofte, Denmark
来源
JOURNAL OF INFECTIOUS DISEASES | 2003年 / 188卷 / 05期
关键词
D O I
10.1086/377183
中图分类号
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号
100102 ;
摘要
Mannose-binding lectin (MBL) mediates protection against infections by using the complement system, but certain microorganisms may increase infectivity by exploiting this host defense system. Thus, it has been speculated whether genetically determined low MBL levels may confer partial protection against certain intracellular microorganisms, such as Mycobacterium tuberculosis. We investigated MBL alleles in 109 culture-positive human immunodeficiency virus-uninfected patients with tuberculosis living in Denmark and 250 white control subjects. Patients and control subjects were divided into 3 different groups defined by undetectable, low, and high serum MBL concentrations, which correlates to deficient, low, and high expressing MBL genotypes. A significantly decreased frequency of patients with the low-expressing MBL genotype was observed in white patients compared to control subjects. The same tendency also was observed in patients of other ethnic origin. It may be hypothesized that heterozygosity for MBL variant alleles, which encodes low serum MBL levels, is associated with protection against clinical tuberculosis.
引用
收藏
页码:777 / 782
页数:6
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