Comparison of the tumor immune microenvironment of primary hormone receptor-negative HER2-positive and triple negative breast cancer

被引：3

作者：

Vos, Hanne ^{[1
,2
]}

Lambein, Kathleen ^{[1
,2
]}

Richard, Francois ^{[3
]}

Marien, Bram ^{[1
,2
]}

Nevelsteen, Ines ^{[1
,2
,4
]}

Punie, Kevin ^{[4
,5
]}

Wildiers, Hans ^{[4
,5
]}

Berben, Lieze ^{[5
]}

Laenen, Annouschka ^{[6
]}

Floris, Giuseppe ^{[4
,7
]}

Desmedt, Christine ^{[3
]}

Smeets, Ann ^{[1
,2
,4
]}

机构：

[1] Katholieke Univ Leuven, Univ Hosp Leuven, Dept Surg Oncol, Leuven, Belgium

[2] Katholieke Univ Leuven, Dept Oncol, Leuven, Belgium

[3] Katholieke Univ Leuven, Lab Translat Breast Canc Res, Dept Oncol, Leuven, Belgium

[4] Univ Hosp Leuven, Multidisciplinary Breast Ctr, Leuven, Belgium

[5] Katholieke Univ Leuven, Dept Gen Med Oncol, Lab Expt Oncol, Univ Hosp Leuven, Leuven, Belgium

[6] Katholieke Univ Leuven, Leuven Biostat & Stat Bioinformat Ctr L BioStat, Leuven, Belgium

[7] Katholieke Univ Leuven, Univ Hosp Leuven, Dept Imaging & Pathol, Lab Translat Cell & Tissue Res, Leuven, Belgium

来源：

NPJ BREAST CANCER | 2021年 / 7卷 / 01期

基金：

欧洲研究理事会;

关键词：

INFILTRATING LYMPHOCYTES; FREE SURVIVAL; TRASTUZUMAB;

D O I：

10.1038/s41523-021-00332-7

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

The vast majority of studies investigating immune checkpoint inhibition (ICI) in patients with breast cancer have focused on triple-negative breast cancer (TNBC). In this study, we compared the tumor immune microenvironment (TIME) between TNBC and hormone receptor-negative HER2-positive breast cancer based on a selection of immune markers at the protein level in an institutional retrospective series. Additionally, we performed a similar comparison using publicly available transcriptomics data. Altogether, the results show a comparable TIME in both groups, with possible implications for the use of ICI in patients with hormone receptor-negative HER2-positive breast tumors.

引用

页数：5

共 50 条

[1] Comparison of the tumor immune microenvironment of primary hormone receptor-negative HER2-positive and triple negative breast cancer
Hanne Vos
Kathleen Lambein
François Richard
Bram Mariën
Ines Nevelsteen
Kevin Punie
Hans Wildiers
Lieze Berben
Annouschka Laenen
Giuseppe Floris
Christine Desmedt
Ann Smeets
[J]. npj Breast Cancer, 7
[2] Two histopathologically different diseases: hormone receptor-positive and hormone receptor-negative tumors in HER2-positive breast cancer
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