Investigation of the inclusion behavior of chlorogenic acid with hydroxypropyl-β-cyclodextrin

被引：44
|
作者：
Chao, Jianbin [1 ]
Wang, Hongfang [1 ]
Zhao, Wei [1 ]
Zhang, Min [1 ]
Zhang, Liwei [1 ]
机构：
[1] Shanxi Univ, Res Inst Appl Chem, Taiyuan 030006, Peoples R China
来源：
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES | 2012年 / 50卷 / 01期
关键词：
Inclusion complex; Chlorogenic acid; Hydroxypropyl-beta-cyclodextrin; Fluorescence; NMR; CAFFEIC ACID; ANTIOXIDANT; COMPLEX;
D O I：
10.1016/j.ijbiomac.2011.11.008
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
The inclusion complexation behavior of chlorogenic acid (CGA) with the hydroxypropyl-beta-cyclodextrin (HP-beta-CD) was investigated in both solution and the solid state by UV-vis and fluorescence spectroscopy, infrared spectroscopy (IR), NMR spectroscopy as well as differential scanning calorimetry (DSC). The experimental results indicate that CGA is able to form an inclusion complex with HP-beta-CD. The inclusion complex has a stoichiometry of 1:1 and the formation constant was calculated to be 155.7 M-1. The antioxidant activity of CGA on complexation with HP-beta-CD increased as compared to uncomplexed CGA. NMR spectroscopic studies show that the aromatic ring and the vinyl group of CGA are deeply included inside the (C) cavity. 2011 Elsevier B.V. All rights reserved.
引用
收藏
页码：277 / 282
页数：6
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