POTENT, SELECTIVE, AND ORALLY ACTIVE CRTH2 ANTAGONISTS FOR ALLERGIC DISEASE

被引:0
|
作者
Burgess, L. [1 ]
Eberhardt, C. [1 ]
Wright, D. [1 ]
Cook, A. [1 ]
Corrette, C. [1 ]
Hunt, K. [1 ]
Clark, C. [1 ]
Romoff, T. [1 ]
Kim, G. [1 ]
Miknis, G. [1 ]
Boys, M. [1 ]
Kraser, C. [1 ]
Moreno, D. [1 ]
Delisle, K. [1 ]
Gomez, A. [1 ]
Hayter, L. [1 ]
Neale, J. [1 ]
Gustafson, C. [1 ]
Rhodes, S. [1 ]
Hingorani, G. [1 ]
Hartley, D. [1 ]
Doherty, G. [1 ]
Chantry, D. [1 ]
机构
[1] ARRAY BIOPHARMA, Boulder, CO USA
关键词
D O I
暂无
中图分类号
Q2 [细胞生物学];
学科分类号
071009 ; 090102 ;
摘要
引用
收藏
页码:284 / 284
页数:1
相关论文
共 50 条
  • [1] Isoquinoline Derivatives as Potent, Selective, and Orally Active CRTH2 Antagonists
    Nishikawa-Shimono, Rie
    Sekiguchi, Yoshinori
    Kawamura, Madoka
    Wakasugi, Daisuke
    Kawanishi, Masahumi
    Watanabe, Kazuhito
    Asakura, Yumiko
    Takaoka, Akiko
    Takayama, Tetsuo
    [J]. CHEMICAL & PHARMACEUTICAL BULLETIN, 2014, 62 (06) : 528 - 537
  • [2] Discovery of novel, potent and orally bioavailable CRTH2 antagonists
    Terasaka, Tadashi
    Ito, Shinji
    Zenkoh, Tatsuya
    Hayashida, Hisashi
    Matsuda, Hiroshi
    Miyata, Junji
    Nagata, Hiroshi
    Takasuna, Yuji
    Kobayashi, Miki
    Takeuchi, Makoto
    Ohta, Mitsuaki
    [J]. ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY, 2011, 241
  • [3] Novel selective orally active CRTH2 antagonists for allergic inflammation developed from in silico derived hits
    Ulven, Trond
    Receveur, Jean-Marie
    Grimstrup, Marie
    Rist, Oystein
    Frimurer, Thomas M.
    Gerlach, Lars-Ole
    Mathiesen, Jesper Mosolff
    Kostenis, Evi
    Uller, Lena
    Hogberg, Thomas
    [J]. JOURNAL OF MEDICINAL CHEMISTRY, 2006, 49 (23) : 6638 - 6641
  • [4] Discovery of a new class of potent, selective, and orally bioavailable CRTH2 (DP2) receptor antagonists for the treatment of allergic inflammatory diseases
    Crosignani, Stefano
    Page, Patrick
    Missotten, Marc
    Colovray, Veronique
    Cleva, Christophe
    Arrighi, Jean-Francois
    Atherall, John
    Macritchie, Jackie
    Martin, Thierry
    Humbert, Yves
    Gaudet, Marilene
    Pupowicz, Doris
    Maio, Maurizio
    Pittet, Pierre-Andre
    Golzio, Lucia
    Giachetti, Claudio
    Rocha, Cynthia
    Bernardinelli, Gerald
    Filinchuk, Yaroslav
    Scheer, Alexander
    Schwarz, Matthias K.
    Chollet, Andre
    [J]. JOURNAL OF MEDICINAL CHEMISTRY, 2008, 51 (07) : 2227 - 2243
  • [5] Discovery of Potent, Selective, and Orally Bioavailable Alkynylphenoxyacetic Acid CRTH2 (DP2) Receptor Antagonists for the Treatment of Allergic Inflammatory Diseases
    Crosignani, Stefano
    Pretre, Adeline
    Jorand-Lebrun, Catherine
    Fraboulet, Gaele
    Seenisamy, Jeyaprakashnarayanan
    Augustine, John Kallikat
    Missotten, Marc
    Humbert, Yves
    Cleva, Christophe
    Abla, Nada
    Daff, Hamina
    Schott, Olivier
    Schneider, Manfred
    Burgat-Charvillon, Fabienne
    Rivron, Delphine
    Hamernig, Ingrid
    Arrighi, Jean-Francois
    Gaudet, Marilene
    Zimmerli, Simone C.
    Juillard, Pierre
    Johnson, Zoe
    [J]. JOURNAL OF MEDICINAL CHEMISTRY, 2011, 54 (20) : 7299 - 7317
  • [6] Azaindoles as potent CRTH2 receptor antagonists
    Simard, Daniel
    Leblanc, Yves
    Berthelette, Carl
    Zaghdane, M. Helmi
    Molinaro, Carmela
    Wang, Zhaoyin
    Gallant, Michel
    Lau, Stephen
    Thao, Trinh
    Hamel, Martine
    Stocco, Rino
    Sawyer, Nicole
    Sillaots, Susan
    Gervais, Francois
    Houle, Robert
    Levesque, Jean-Francois
    [J]. BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 2011, 21 (02) : 841 - 845
  • [7] Discovery of novel and potent CRTH2 antagonists
    Ito, Shinji
    Terasaka, Tadashi
    Zenkoh, Tatsuya
    Matsuda, Hiroshi
    Hayashida, Hisashi
    Nagata, Hiroshi
    Imamura, Yoshimasa
    Kobayashi, Miki
    Takeuchi, Makoto
    Ohta, Mitsuaki
    [J]. BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 2012, 22 (02) : 1194 - 1197
  • [8] Potent And Selective CRTH2 Antagonists Are Efficacious In Models Of Asthma, Allergic Rhinitis (AR) And Atopic Dermatitis (AD)
    Carter, L. L.
    Shiraishi, Y.
    Shin, Y.
    Burgess, L.
    Eberhardt, C.
    Wright, A. D.
    Klopfenstein, N.
    McVean, M.
    Gomez, A.
    Chantry, D.
    Cook, A.
    Takeda, K.
    Gelfand, E. W.
    [J]. JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY, 2010, 125 (02) : AB124 - AB124
  • [9] Isoquinoline derivatives as potent CRTH2 receptor antagonists: Lead generation, optimization, and pharmacological effects of the potent CRTH2 receptor antagonists
    Shimono, Rie Nishikawa
    Sekiguchi, Yoshinori
    Koami, Takeshi
    Kawamura, Madoka
    Wakasugi, Daisuke
    Kawanishi, Masafumi
    Watanabe, Kazuhito
    Asakura, Yumiko
    Takaoka, Akiko
    Yamanobe, Susumu
    Takayama, Tetsuo
    [J]. ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY, 2013, 245
  • [10] Tetrahydroquinolines as CRTH2 antagonists
    Liu, Jiwen
    Wang, Yingcai
    Sun, Ying
    Tang, Lucy
    Marshall, Derek
    Tonn, George
    Medina, Julio C.
    [J]. ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY, 2006, 231