Development of Electrochemical Aptasensor for Label-Free Glioma Cell Detection

This work explored the fabrication of a functionalized graphene-and-aptamer AS1411-based electrochemical sensor to achieve tag-free cancer cell determination. The proposed electrochemical aptasensor could distinguish between normal cells and glioma cells with a low detection limit due to the excellent binding affinity and specificity of AS1411 to the overexpressed nucleolin on the surface of the glioma cells.