The structure of erastin-bound xCT-4F2hc complex reveals molecular mechanisms underlying erastin-induced ferroptosis

被引：76
|
作者：
Yan, Renhong [1 ,9 ]
Xie, Enjun [2 ,3 ]
Li, Yaning [4 ]
Li, Jin [2 ,3 ]
Zhang, Yuanyuan
Chi, Ximin
Hu, Xueping [5 ]
Xu, Lei [6 ]
Hou, Tingjun [5 ]
Stockwell, Brent R. [7 ,8 ]
Min, Junxia [2 ]
Zhou, Qiang [1 ]
Wang, Fudi [2 ,3 ]
机构：
[1] Westlake Univ, Sch Life Sci, Westlake Inst Adv Study,Inst Biol, Westlake Lab Life Sci & Biomed,Key Lab Struct Bio, Hangzhou, Zhejiang, Peoples R China
[2] Zhejiang Univ, Sch Med, State Key Lab Expt Hematol,Affiliated Hosp 1, Inst Translat Med,Canc Ctr,Sch Publ Hlth,Affiliat, Hangzhou, Zhejiang, Peoples R China
[3] Univ South China, Hengyang Med Sch, Sch Publ Hlth, Affiliated Hosp 2,Affiliated Hosp 1,Basic Med Sci, Hengyang, Hunan, Peoples R China
[4] Tsinghua Univ, Sch Life Sci, Beijing Adv Innovat Ctr Struct Biol, Tsinghua Peking Joint Ctr Life Sci, Beijing, Peoples R China
[5] Zhejiang Univ, Coll Pharmaceut Sci, Hangzhou Inst Innovat Med, Hangzhou, Zhejiang, Peoples R China
[6] Jiangsu Univ Technol, Inst Bioinformat & Med Engn, Changzhou, Jiangsu, Peoples R China
[7] Columbia Univ, Dept Biol Sci, New York, NY 10027 USA
[8] Columbia Univ, Dept Chem, New York, NY 10027 USA
[9] Southern Univ Sci & Technol, Dept Biochem, Sch Med, Shenzhen, Guangdong, Peoples R China
来源：
CELL RESEARCH | 2022年 / 32卷 / 07期
基金：
中国国家自然科学基金; 国家重点研发计划;
关键词：
D O I：
10.1038/s41422-022-00642-w
中图分类号：
Q2 [细胞生物学];
学科分类号：
071009 ; 090102 ;
摘要：
引用
收藏
页码：687 / 690
页数：4
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