β-Cyclodextrin/Fe3O4 nanocomposites for an electrochemical non-enzymatic cholesterol sensor

被引:25
|
作者
Willyam, Shella Jeniferiani [1 ]
Saepudin, Endang [1 ]
Ivandini, Tribidasari Anggraningrum [1 ]
机构
[1] Univ Indonesia, Fac Math & Nat Sci FMIPA, Dept Chem, Depok 16424, Indonesia
关键词
METHYLENE-BLUE; FOODS; CHROMATOGRAPHY; ELECTRODE;
D O I
10.1039/d0ay00933d
中图分类号
O65 [分析化学];
学科分类号
070302 ; 081704 ;
摘要
A sensitive, specific, and miniaturized non-enzymatic cholesterol sensor was prepared based on the competition of inclusion complex formation between beta-cyclodextrin (BCD) and cholesterol, and between BCD and methylene blue (MB). BCD was immobilized on the surface of Fe3O4 magnetic nanoparticles instead of the electrode surface to increase the kinetic rate and enhance the sensitivity of the sensor. Furthermore, the use of magnetic nanocomposites and a screen-printed carbon electrode reduces the overall analysis time and simplifies the sample measurement procedures, making the sensor suitable for point-of-care analysis. The electrochemical measurement results of MB, released from the reactions between BCD and solutions containing various concentrations of cholesterol were used as the input signal to calculate the cholesterol concentrations. A good linearity as well as an excellent accuracy and repeatability in the concentration range of 0-150 mu M with an estimated limit of detection of 2.88 mu M could be achieved by using the amperometric technique at a constant potential of-0.43 V. The sensor showed a good selectivity in the presence of 1 mM concentrations of interfering agents, including NaCl, CaCl2, glycine, glucose, and ascorbic acid. Furthermore, a validation performed for cholesterol determination in milk samples was in agreement with the measurements performed by using the HPLC method, suggesting that the developed sensor is reliable.
引用
收藏
页码:3454 / 3461
页数:8
相关论文
共 50 条
  • [1] Solvothermal synthesis of Fe3O4 nanospheres for high-performance electrochemical non-enzymatic glucose sensor
    Xu, Jiasheng
    Sun, Yuting
    Zhang, Jie
    [J]. SCIENTIFIC REPORTS, 2020, 10 (01)
  • [2] Solvothermal synthesis of Fe3O4 nanospheres for high-performance electrochemical non-enzymatic glucose sensor
    Jiasheng Xu
    Yuting Sun
    Jie Zhang
    [J]. Scientific Reports, 10
  • [3] Non-enzymatic electrochemical detection of dopamine in blood serum based on porous nitrogen-doped graphene/Fe3O4 nanocomposites
    Wang, Yichi
    Sheng, Weiqin
    Wu, Jun
    Xu, Junming
    Song, Kaixin
    [J]. MICRO & NANO LETTERS, 2020, 15 (11) : 774 - 778
  • [4] Non-enzymatic electrochemical detection of cholesterol using β-cyclodextrin functionalized graphene
    Agnihotri, Nidhi
    Chowdhury, Ankan Dutta
    De, Amitabha
    [J]. BIOSENSORS & BIOELECTRONICS, 2015, 63 : 212 - 217
  • [5] A peroxidase biomimetic system based on Fe3O4 nanoparticles in non-enzymatic sensors
    Ramos Guivar, Juan A.
    Fernandes, Edson G. R.
    Zucolotto, Valtencir
    [J]. TALANTA, 2015, 141 : 307 - 314
  • [6] Metal-Organic-Framework FeBDC-Derived Fe3O4 for Non-Enzymatic Electrochemical Detection of Glucose
    Abrori, Syauqi Abdurrahman
    Septiani, Ni Luh Wulan
    Nugraha
    Anshori, Isa
    Suyatman
    Suendo, Veinardi
    Yuliarto, Brian
    [J]. SENSORS, 2020, 20 (17) : 1 - 16
  • [7] Novel Magnetic Nanocomposites Comprising Reduced Graphene Oxide/Fe3O4/Gelatin Utilized in Ultrasensitive Non-Enzymatic Biosensing
    Naghib, Seyed Morteza
    Rahmanian, Mehdi
    Majidzadeh-A, Keivan
    Asiaei, Sasan
    Vahidi, Omid
    [J]. INTERNATIONAL JOURNAL OF ELECTROCHEMICAL SCIENCE, 2016, 11 (12): : 10256 - 10269
  • [8] (Fe3O4)-graphene oxide as a novel magnetic nanomaterial for non-enzymatic determination of phenylalanine
    Omidinia, Eskandar
    Shadjou, Nasrin
    Hasanzadeh, Mohammad
    [J]. MATERIALS SCIENCE & ENGINEERING C-MATERIALS FOR BIOLOGICAL APPLICATIONS, 2013, 33 (08): : 4624 - 4632
  • [9] Enhanced sensing performance of flexible non-enzymatic electrochemical glucose sensors using hollow Fe3O4 nanospheres of controllable morphologies
    Zhou, Fan
    Wang, Jiyuan
    Tang, Yimei
    Song, Xuhang
    Zhou, Wanrong
    Li, Yan
    Gao, Feng
    [J]. CERAMICS INTERNATIONAL, 2024, 50 (20) : 38009 - 38021
  • [10] Fabrication of Fe3O4 nanotube arrays for high-performance non-enzymatic detection of glucose
    Chen, Ying-Chu
    Hsu, Jui-Hung
    Chen, Zhong-Bo
    Lin, Yan-Gu
    Hsu, Yu-Kuei
    [J]. JOURNAL OF ELECTROANALYTICAL CHEMISTRY, 2017, 788 : 144 - 149