Discovery of novel FMS kinase inhibitors as anti-inflammatory agents

被引：44

作者：

Illig, Carl R. ^{[1
]}

Chen, Jinsheng ^{[1
]}

Wall, Mark J. ^{[1
]}

Wilson, Kenneth J. ^{[1
]}

Ballentine, Shelley K. ^{[1
]}

Rudolph, M. Jonathan ^{[1
]}

DesJarlais, Renee L. ^{[1
]}

Chen, Yanmin ^{[1
]}

Schubert, Carsten ^{[1
]}

Petrounia, Ioanna ^{[1
]}

Crysler, Carl S. ^{[1
]}

Molloy, Christopher J. ^{[1
]}

Chaikin, Margery A. ^{[1
]}

Manthey, Carl L. ^{[1
]}

Player, Mark R. ^{[1
]}

Tomczuk, Bruce E. ^{[1
]}

Meegalla, Sanath K. ^{[1
]}

机构：

[1] Johnson & Johnson Pharmaceut Res & Dev, Spring House, PA 19477 USA

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 2008年 / 18卷 / 05期

关键词：

FMS; CSF-1R; M-CSF; colony stimulating factor-1; macrophages; anti-inflammatory activity;

D O I：

10.1016/j.bmcl.2008.01.059

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

The optimization of the arylamide lead 2 resulted in identification of a highly potent series of 2,4-disubstituted arylamides. Compound 8 (FMS kinase IC50 = 0.0008 mu M) served as a proof-of-concept candidate in a collagen-induced model of arthritis in mice. (c) 2008 Elsevier Ltd. All rights reserved.

引用

页码：1642 / 1648

页数：7

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