Microbiome Metabolite Mimics Accelerate Drug Discovery

被引：7
|
作者：
Nuzzo, Andrea [1 ]
Brown, James R. [1 ]
机构：
[1] GlaxoSmithKline R&D, Human Genet, Computat Biol, Collegeville, PA 19426 USA
来源：
TRENDS IN MOLECULAR MEDICINE | 2020年 / 26卷 / 05期
关键词：
D O I：
10.1016/j.molmed.2020.03.006
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
A recent study by Dvorak et al. supports metabolite mimicry as a drug development strategy. A potent agonist of the human pregnane X receptor (hPXR) was designed from two ligands that are products of the microbial catabolism of tryptophan. Its validity was demonstrated in cellular assays and a murine colitis model expressing hPXR by a significant reduction in inflammation biomarkers.
引用
收藏
页码：435 / 437
页数：3
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