Human immunodeficiency virus-1 B and non-B subtypes with the same drug resistance pattern respond similarly to antiretroviral therapy

被引：6

作者：

Franzetti, M. ^{[1
]}

Violin, M. ^{[1
]}

Casazza, G. ^{[2
]}

Meini, G. ^{[3
]}

Callegaro, A. ^{[4
]}

Corsi, P. ^{[5
]}

Maggiolo, F. ^{[6
]}

Pignataro, A. R. ^{[7
]}

Paolucci, S. ^{[8
]}

Gianotti, N. ^{[9
]}

Francisci, D. ^{[10
]}

Rossotti, R. ^{[11
]}

Filice, G. ^{[12
]}

Carli, T. ^{[13
]}

Zazzi, M. ^{[3
]}

Balotta, C. ^{[1
]}

机构：

[1] Univ Milan, Sect Infect Dis & Immunopathol, Dept Clin Sci L Sacco, Milan, Italy

[2] Univ Milan, Unit Stat & Biometry, Milan, Italy

[3] Univ Siena, Dept Biotechnol, I-53100 Siena, Italy

[4] Osped Riuniti Bergamo, Dept Microbiol & Virol, Bergamo, Italy

[5] Careggi Hosp, Dept Infect Dis, Florence, Italy

[6] Osped Riuniti Bergamo, Dept Infect Dis, Bergamo, Italy

[7] Ist Sci San Raffaele, Dept Virol, I-20132 Milan, Italy

[8] Fdn IRCCS Policlin San Matteo, Mol Virol Unit, Pavia, Italy

[9] Ist Sci San Raffaele, Dept Infect Dis, I-20132 Milan, Italy

[10] Univ Perugia, Infect Dis Clin, I-06100 Perugia, Italy

[11] A Manzoni Hosp, Infect Dis Clin, Lecce, Italy

[12] Fdn IRCCS Policlin San Matteo, Dept Infect Dis, Pavia, Italy

[13] Misericordia Hosp, Dept Infect Dis, Grosseto, Italy

来源：

CLINICAL MICROBIOLOGY AND INFECTION | 2012年 / 18卷 / 03期

关键词：

Antiretroviral treatment; drug resistance; HIV-1; evolution; non-B subtypes; REVERSE-TRANSCRIPTASE; HIV-1; SUBTYPES; PROTEASE; PREVALENCE; IMPACT; STRAINS; NAIVE;

D O I：

10.1111/j.1469-0691.2011.03740.x

中图分类号：

R51 [传染病];

学科分类号：

100401 ;

摘要：

We analysed the 12-week virological response to protease inhibitor (PI) or non-nucleoside reverse transcriptase inhibitor (NNRTI) therapy in 1108 patients carrying B or non-B human immunodeficiency virus (HIV)-1 subtypes with matched resistance mutation patterns. Response rates were not significantly different for non-B and B subtypes stratified for treatment status (51.5% vs. 41.5% in naive patients; 46.7% vs. 38.7% in experienced patients) or regimens (46.9% vs. 39.7% with PI; 56.7% vs. 40% with NNRTI). No difference in response was detected in patients harbouring B and non-B subtypes with any resistance profile. Further studies are advisable to fully test this approach on larger datasets.

引用

页码：E66 / E70

页数：5

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