Calix[6]arene derivative as chromogenic sensor for anti-hypertensive drugs

A simple, rapid, and sensitive spectrophotometric method has been developed for the determination of atenolol, propranolol hydrochloride and metaprolol tartarate. The method is based on the reaction of these drugs as n-electron donors with acceptor groups on macrocyclic ring of calixarene. Due to the rapid development of color at ambient temperatures, the chromogenic calix[6]arene derivative can be used for the determination of these beta-adrenergic blocking drugs. The association constants (K,) and free energies for the complexes have been determined. The proposed method can be used to determine the drugs in pharmaceutical tablets and urine.