Adjuvant therapy in renal cell carcinoma

被引：34

作者：

Massari, Francesco ^{[1
]}

Di Nunno, Vincenzo ^{[1
]}

Ciccarese, Chiara ^{[2
]}

Graham, Jeffrey ^{[3
]}

Porta, Camillo ^{[4
]}

Comito, Francesca ^{[1
]}

Cubelli, Marta ^{[1
]}

Iacovelli, Roberto ^{[2
]}

Heng, Daniel Y. C. ^{[3
]}

机构：

[1] St Orsola Marcello Malpighi Hosp, Div Oncol, Bologna, Italy

[2] AOUI Verona, Dept Med Oncol, Verona, Italy

[3] Univ Calgary, Dept Med Oncol, Tom Baker Canc Ctr, Calgary, AB, Canada

[4] IRCCS San Matteo Univ Hosp Fdn, Div Med Oncol, Pavia, Italy

来源：

CANCER TREATMENT REVIEWS | 2017年 / 60卷

关键词：

Adjuvant treatment; Tyrosine kinases inhibitors; Renal cell carcinoma; Clear cell renal cell carcinoma; Immunotherapy; PHASE-III; INTERFERON-ALPHA; HIGH-RISK; RADICAL NEPHRECTOMY; DOUBLE-BLIND; RANDOMIZED-TRIAL; STAGE-II; BEVACIZUMAB; SUNITINIB; CANCER;

D O I：

10.1016/j.ctrv.2017.09.004

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Several drugs have demonstrated clinical activity in metastatic renal cell carcinoma (mRCC). The identification of key metabolic pathways has led to the development of novel targeted therapies which have drastically changed the treatment paradigm of mRCC. Moreover, immune-checkpoint inhibitors have recently shown significant activity in advanced disease. Despite these advancements, the role of adjuvant therapy in localized, non-metastatic RCC remains unclear. The utility of many of these agents in the adjuvant setting is currently being actively explored. In this review, we will summarize the main clinical trials investigating adjuvant therapy in renal cell carcinoma, focusing primarily on immunotherapy and targeted agents. (c) 2017 Elsevier Ltd. All rights reserved.

引用

页码：152 / 157

页数：6

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