Genetics Meets Epigenetics in Treg Cells and Autoimmunity

被引：4
|
作者：
Garcia, Paula A. Agudelo [1 ,2 ,3 ]
Berger, Shelley L. [1 ,2 ,3 ]
机构：
[1] Univ Penn, Epigenet Inst, Dept Cell & Dev Biol, Philadelphia, PA 19104 USA
[2] Univ Penn, Epigenet Inst, Dept Genet, Philadelphia, PA 19104 USA
[3] Univ Penn, Dept Biol, Epigenet Inst, Philadelphia, PA 19104 USA
来源：
IMMUNITY | 2020年 / 52卷 / 06期
关键词：
D O I：
10.1016/j.immuni.2020.05.009
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
Most autoimmunity-associated SNPs in the genome map to noncoding regulatory regions in T cells, but the nature of underlying epigenetic mechanisms and any normal purpose in T cell differentiation remain unclear. In this issue of Immunity, Ohkura et al. establish that crucial SNPs linked to autoimmune disease are enriched in DNA regions of CpG demethylation that govern Treg cell development and function.
引用
收藏
页码：897 / 899
页数：4
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