The critical contribution of TGF-β to the induction of Foxp3 expression and regulatory T cell function

被引：85
|
作者：
Shevach, Ethan M. [1 ]
Tran, Dat Q. [1 ]
Davidson, Todd S. [1 ]
Andersson, John [1 ]
机构：
[1] NIAID, Immunol Lab, NIH, Bethesda, MD 20892 USA
来源：
EUROPEAN JOURNAL OF IMMUNOLOGY | 2008年 / 38卷 / 04期
关键词：
Foxp3; IL-2; Regulatory T cells; TGF-beta;
D O I：
10.1002/eji.200738111
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
Stimulation of mouse CD4(+) T cells in the presence of TGF-beta results in the expression of Foxp3 and induction of T-reg function. Stimulation of human CD4(+) T cells under similar conditions results in the expression of Foxp3, but the cells lack regulatory cell function. TGF-beta expressed on the surface of T-reg also induces Foxp3 expression and T-reg function in responder cells. Both of these mechanisms may play a role in vivo in the induction of antigen-specific extra-thymic T-reg.
引用
收藏
页码：915 / 917
页数：3
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