Identification of cardiac liability in drug discovery using automated patch clamp: experimental and technical considerations for high throughput recordings of NaV1.5 and hERG

被引：0

作者：

Rotordam, Maria Giustina ^{[1
]}

Obergrussberger, Alison ^{[1
]}

Brinkwirth, Nina ^{[1
]}

Takasuna, Kiyoshi ^{[2
]}

Becker, Nadine ^{[1
]}

Horvath, Andras ^{[1
]}

Furukawa, Hatsue ^{[2
]}

Hasegawa, Yuka ^{[3
]}

Oka, Takayuki ^{[4
]}

Fertig, Niels ^{[1
]}

Stoelzle-Feix, Sonja ^{[1
]}

机构：

[1] Nanion Technol, Munich, Germany

[2] Axcelead Drug Discovery Partners Inc, Kanagawa, Japan

[3] Nanion Technol, Kanagawa, Japan

[4] Nanion Technol KK, Tokyo, Japan

来源：

BIOPHYSICAL JOURNAL | 2022年 / 121卷 / 03期

关键词：

D O I：

暂无

中图分类号：

Q6 [生物物理学];

学科分类号：

071011 ;

摘要：

2434-Pos

引用

页码：503A / 503A

页数：1

共 20 条

[1] Reliable identification of cardiac liability in drug discovery using automated patch clamp: Experimental and technical considerations for high throughput recordings of NaV1.5 and hERG
Rotordam, Maria Giustina
Obergrussberger, Alison
Brinkwirth, Nina
Takasuna, Kiyoshi
Becker, Nadine
Horvath, Andras
Furukawa, Hatsue
Hasegawa, Yuka
Oka, Takayuki
Fertig, Niels
Stoelzle-Feix, Sonja
[J]. JOURNAL OF PHARMACOLOGICAL AND TOXICOLOGICAL METHODS, 2022, 117
[2] Simultaneous measurement of cardiac NAV1.5 and hERG currents using the automated Qube® patch clamp platform
Guo, Donglin
Sauter, Daniel R.
Jenkinson, Stephen
[J]. JOURNAL OF PHARMACOLOGICAL AND TOXICOLOGICAL METHODS, 2019, 99
[3] Reliable identification of hERG liability in drug discovery by automated patch clamp
Stoelzle-Feix, Sonja
Brinkwirth, Nina
Becker, Nadine
Haarmann, Claudia
Knox, Ronald
Hampl, Martin
George, Michael
Vogel, Marius
Haedo, Rodolfo
Fertig, Niels
[J]. JOURNAL OF PHARMACOLOGICAL AND TOXICOLOGICAL METHODS, 2020, 105
[4] Reliable Identification of hERG Liability in Drug Discovery by Automated Patch Clamp
George, Michael
Haedo, Rodolfo
Brinkwirth, Nina
Becker, Nadine
Haarmann, Claudia S.
Obergrussberger, Alison
Knox, Ronald
Hampl, Martin
Fertig, Niels
[J]. BIOPHYSICAL JOURNAL, 2020, 118 (03) : 116A - 117A
[5] Reliable identification of cardiac conduction abnormalities in drug discovery using automated patch clamp II: Best practices for Nav1.5 peak current in a high throughput screening environment
Rotordam, Maria Giustina
Obergrussberger, Alison
Brinkwirth, Nina
Takasuna, Kiyoshi
Becker, Nadine
Horvth, Andras
Goetze, Tom A.
Rapedius, Markus
Furukawa, Hatsue
Hasegawa, Yuka
Oka, Takayuki
Fertig, Niels
Stoelzle-Feix, Sonja
[J]. JOURNAL OF PHARMACOLOGICAL AND TOXICOLOGICAL METHODS, 2021, 112
[6] Early identification of hERG liability in drug discovery programs by automated patch clamp
Danker, Timm
Moeller, Clemens
[J]. FRONTIERS IN PHARMACOLOGY, 2014, 5
[7] Reliable identification of cardiac liability in drug discovery using automated patch clamp III: Best practices for CaV1.2 current in a high throughput screening environment
Obergrussberger, Alison
Brinkwirth, Nina
Becker, Nadine
Takasuna, Kiyoshi
Voemel, Matthias
Rimpel, Sarah
Herbold, Susanne
Glaser, Nina
Schnellbaecher, Thomas
Furukawa, Hatsue
Hasegawa, Yuka
Oka, Takayuki
Strassmaier, Tim
Randolph, Aaron
Fertig, Niels
Stoelzle-Feix, Sonja
[J]. JOURNAL OF PHARMACOLOGICAL AND TOXICOLOGICAL METHODS, 2023, 123
[8] Simultaneous assessment of compound activity on cardiac Nav1.5 peak and late currents in an automated patch clamp platform
Guo, Donglin
Jenkinson, Stephen
[J]. JOURNAL OF PHARMACOLOGICAL AND TOXICOLOGICAL METHODS, 2019, 99
[9] High throughput hERG assay using the automated patch-clamp system; Optimization of experimental condition
Katayama, Y
Tsuzaki, K
Yonezawa, K
Amagai, M
Abe, K
Tsurubuchi, Y
[J]. JOURNAL OF PHARMACOLOGICAL SCIENCES, 2004, 94 : 157P - 157P
[10] Assessing the feasibility of measuring hERG drug block kinetics using high throughput automated patch-clamp
Windley, Monique J.
Farr, Jessica
Humphreys, David T.
Vandenberg, Jamie I.
Hill, Adam P.
[J]. JOURNAL OF PHARMACOLOGICAL AND TOXICOLOGICAL METHODS, 2022, 117

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