Interstitial Lung Disease Associated with Lung Cancer: A Case-Control Study

被引:16
|
作者
Gibiot, Quentin [1 ,2 ]
Monnet, Isabelle [1 ]
Levy, Pierre [3 ]
Brun, Anne-Laure [4 ,5 ]
Antoine, Martine [6 ]
Chouaid, Christos [1 ,2 ]
Cadranel, Jacques [7 ,8 ]
Naccache, Jean-Marc [7 ]
机构
[1] Ctr Hosp Intercommunal Creteil, Serv Pneumol, F-94000 Creteil, France
[2] Univ Paris Est Creteil, Fac Med, F-94000 Creteil, France
[3] Sorbonne Univ, Hop Tenon, AP HP, Inst Pierre Louis Sante Publ,EPAR Team,Dept Sante, F-75020 Paris, France
[4] Hop Cochin, AP HP, Serv Radiol, F-75014 Paris, France
[5] Univ Paris 05, Fac Med, F-75020 Paris, France
[6] Hop Tenon, AP HP, Serv Anat & Cytol Pathol, F-75020 Paris, France
[7] Hop Tenon, AP HP, Site Constitutif Ctr Reference Malad Pulm Rares O, Serv Pneumol, F-75020 Paris, France
[8] Univ Paris 05, Fac Med, F-75020 Paris, France
关键词
interstitial lung disease; lung cancer; prognosis; retrospective; outcomes; IDIOPATHIC PULMONARY-FIBROSIS; CLINICAL-PRACTICE GUIDELINES; SURVIVAL; CHEMOTHERAPY; DIAGNOSIS; IMPACT; RISK; CLASSIFICATION; ALVEOLITIS; PNEUMONIA;
D O I
10.3390/jcm9030700
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
Interstitial lung disease (ILD) seems to be associated with an increased risk of lung cancer (LC) and to have a poorer prognosis than LC without ILD. The frequency of ILD in an LC cohort and its prognosis implication need to be better elucidated. This retrospective, observational, cohort study evaluated the frequency of ILD among LC patients (LC-ILD) diagnosed over a 2-year period. LC-ILD patients' characteristics were compared to those with LC without ILD (LC-noILD). Lastly, we conducted a case-control study within this cohort, matching three LC-noILDs to each LC-ILD patient, to evaluate the ILD impact on LC patients' prognoses. Among 906 LC patients, 49 (5.4%) also had ILD. Comparing LC-ILD to LC-noILD patients, respectively, more were men (85.7% vs. 66.2%; p = 0.02); adenocarcinomas were less frequent (47.1% vs. 58.7%, p = 0.08); median [range] and overall survival was shorter: (9 [range: 0.1-39.4] vs. 17.5 [range: 0.8-50.4] months; p = 0.01). Multivariate analysis (hazard ratio [95% confidence interval]) retained two factors independently associated with LC risk of death: ILD (1.79 [1.22-2.62]; p = 0.003) and standard-of-care management (0.49 [0.33-0.72]; p < 0.001). Approximately 5% of patients with a new LC diagnosis had associated ILD. ILD was a major prognosis factor for LC and should be taken into consideration for LC management. Further studies are needed to determine the best therapeutic strategy for the LC-ILD population.
引用
收藏
页数:10
相关论文
共 50 条
  • [1] Interstitial lung disease in Japanese patients with lung cancer - A cohort and nested case-control study
    Kudoh, Shoji
    Kato, Harubumi
    Nishiwaki, Yutaka
    Fukuoka, Masahiro
    Nakata, Kouichiro
    Ichinose, Yukito
    Tsuboi, Masahiro
    Yokota, Soichiro
    Nakagawa, Kazuhiko
    Suga, Moritaka
    Jiang, Haiyi
    Itoh, Yohji
    Armour, Alison
    Watkins, Claire
    Higenbottam, Tim
    Nyberg, Fredrik
    [J]. AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE, 2008, 177 (12) : 1348 - 1357
  • [2] Are interstitial lung abnormalities associated with COPD? A nested case-control study
    Bozzetti, Francesca
    Paladini, Ilaria
    Rabaiotti, Enrico
    Franceschini, Alessandro
    Alfieri, Veronica
    Chetta, Alfredo
    Crisafulli, Ernesto
    Silva, Mario
    Pastorino, Ugo
    Sverzellati, Nicola
    [J]. INTERNATIONAL JOURNAL OF CHRONIC OBSTRUCTIVE PULMONARY DISEASE, 2016, 11 : 1087 - 1096
  • [3] Association between ischaemic heart disease and interstitial lung disease: A case-control study
    Ponnuswamy, A.
    Manikandan, R.
    Sabetpour, A.
    Keeping, I. M.
    Finnerty, J. P.
    [J]. RESPIRATORY MEDICINE, 2009, 103 (04) : 503 - 507
  • [4] Clinical Characteristics of Dermatomyositis with Interstitial Lung Disease: A Retrospective Case-Control Study
    Weng, Chenghua
    Ding, Zongnan
    Zhou, Yiqun
    Yang, Qinyi
    Xue, Leixi
    Zhang, Lei
    Wang, Gang
    Liu, Zhichun
    [J]. RHEUMATOLOGY AND THERAPY, 2023, 10 (03) : 635 - 648
  • [5] Predictors of postoperative acute exacerbation of interstitial lung disease: a case-control study
    Hosoki, Keisuke
    Mikami, Yu
    Urushiyama, Hirokazu
    Souma, Kunihiko
    Kawamura, Gaku
    Uchida, Kanji
    Nagase, Takahide
    Jo, Taisuke
    [J]. BMJ OPEN RESPIRATORY RESEARCH, 2020, 7 (01)
  • [6] PREVIOUS PULMONARY DISEASE AND LUNG CANCER - A CASE-CONTROL STUDY
    DAMON, A
    MCCLUNG, JP
    [J]. JOURNAL OF CHRONIC DISEASES, 1967, 20 (02): : 59 - &
  • [7] TERT expression in lung cancer associated with IPF: a case-control study
    Gomatou, Georgia
    Masaoutis, Christos
    Vamvakaris, Ioannis
    Bouros, Evangelos
    Bouros, Demosthenes
    [J]. EUROPEAN RESPIRATORY JOURNAL, 2021, 58
  • [8] Prognostic Significance of Autoantibody Positivity in Interstitial Lung Disease: A Retrospective Case-Control Study
    Kampolis, Christos F.
    Venetsanopoulou, Aliki I.
    Karakontaki, Fotini
    Polychronopoulos, Vlassis
    Vlachoyiannopoulos, Panayiotis G.
    Tzioufas, Athanasios G.
    [J]. ARTHRITIS & RHEUMATOLOGY, 2016, 68
  • [9] Risk factors associated with lung cancer - a case-control study in Tianjin, China
    Chen, K. X.
    Xu, W. L.
    Jia, Z. L.
    Yu, M.
    Wang, Q. S.
    Dong, S. F.
    Wang, J. F.
    Wang, P. P.
    [J]. EJC SUPPLEMENTS, 2005, 3 (02): : 160 - 161
  • [10] Is opium use associated with an increased risk of lung cancer? A case-control study
    Naghibzadeh-Tahami, Ahmad
    Marzban, Maryam
    Yazdi-Feyzabadi, Vahid
    Dabiri, Shahryar
    Mohseni, Shokrollah
    Rayeni, Reza Abbasi
    Fekri, Mitra Samareh
    Larizadeh, Mohammad Hasan
    Karimpour, Behnaz
    Khanjani, Narges
    [J]. BMC CANCER, 2020, 20 (01)